下载 "The Effects of Cannabis (Marijuana) on the Brain & Body | Huberman Lab Podcast #92"

In this episode, I discuss cannabis (aka marijuana), including the biological mechanisms underlying its effects on the mind and body, its known medical applications, its impact on libido, creativity, hunger, hormones and more. I also cover the known adverse health consequences of chronic and even acute (one-time) use and the factors that determine if cannabis is helpful or harmful. Additionally, I detail how the various strains of cannabis: sativa, indica and hybrid strains, can produce such divergent effects depending on the strain type, THC-to-CBD ratio, total dosage, and frequency of use. I review why cannabis can impact speech patterns and one’s propensity to develop anxiety/depression during and after use and, in some individuals, paranoia. As the legal landscape for cannabis is rapidly evolving, this episode should interest a wide audience, including former/current cannabis users, those in the medical, sports, law enforcement, and educational communities and, of course, children, teenagers, and parents. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Levels: https://join.levelshealth.com/huberman2/?partner=HUBERMAN Thesis: https://takethesis.com/huberman InsideTracker: https://info.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Huberman Lab Premium https://www.hubermanlab.com/premium Social & Website Instagram: https://www.facebook.com/unsupportedbrowser Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/unsupportedbrowser TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com/ Newsletter: https://www.hubermanlab.com/newsletter Articles Inspired by Mary Jane? Mechanisms underlying enhanced creativity in cannabis users: https://linkinghub.elsevier.com/retrieve/pii/S1053810017303744 Adults with a history of recreational cannabis use have altered speech production: https://www.sciencedirect.com/science/article/abs/pii/S0376871621004580?via%3Dihub Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study: https://link.springer.com/article/10.1007/s00213-017-4601-1?error=cookies_not_supported&code=b234c890-23f1-4d26-a94a-0be10343c35f Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning: https://www.nature.com/articles/s41398-022-01956-4?error=cookies_not_supported&code=a359c3e5-98cc-4621-b763-1b3e979e5673 Association of cannabis potency with mental ill health and addiction: a systematic review: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00161-4/fulltext Other Links and Resources NSDR Protocol with Dr. Huberman on YouTube: https://www.youtube.com/watch?v=AKGrmY8OSHM Timestamps 00:00:00 Cannabis (Marijuana) 00:04:46 New Huberman Lab Premium Membership 00:07:03 Tool: Non-Sleep Deep Rest (NSDR), Sleep & Anxiety 00:10:08 Levels, Thesis, InsideTracker 00:14:01 Momentous Supplements 00:15:08 Cannabis Strains, Psychoactive Compounds: THC & CBD 00:19:34 Sativa vs. Indica, Stimulant vs. Relaxation Effects 00:25:55 Hybrid Cannabis Strains, Type 1, 2 & 3 Strains 00:30:41 AG1 (Athletic Greens) 00:31:56 Naturally Occurring Receptors: Nicotinic & Cannabinoid Receptors (CB1) 00:40:35 THC, CBD vs. Endogenous Cannabinoids, Dependence 00:43:14 Endogenous Cannabinoids, Cannabinoid Receptors & Nervous System Function 00:53:07 Biological Effects of Cannabis 00:56:29 Cannabis Sativa & Subjective Effects: Mood, Stress, Alertness, Paranoia 01:04:58 Cannabis Indica & Subjective Effects, Memory, Dosage 01:09:41 Brain Areas Affected by THC & CBD, Side Effects 01:16:08 Creativity: Convergent vs. Divergent Thinking & Dopamine 01:26:41 Does Cannabis Increase Creativity? 01:35:08 Chronic Cannabis Use & Changes in Speech Patterns 01:46:46 Cannabis & Libido, Dopamine & Prolactin 01:56:55 Cannabis & Hormones: Prolactin, Testosterone, Estrogen & Fertility 02:06:53 Smoking/Vaping Tobacco or Cannabis & Negative Health Consequences 02:10:06 Avoiding Cannabis During Pregnancy/Breastfeeding, Fetal Neural Development 02:18:13 Negative Health Consequences of Cannabis, Anxiety & Depression, Tolerance 02:25:57 Cannabis Use & Adolescence/Young Adulthood, Predisposition to Psychosis 02:34:36 Adolescent Cannabis Use: Brain Development & Mental Health Disorders 02:41:44 Cannabis & Pain Management, Divergent Effects of Cannabis 02:44:54 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Premium Channel, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook, LinkedIn Disclaimer: https://www.hubermanlab.com/disclaimer Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com/