下载 "Turbo cancers part 2: the role of IgG4! (update #139)"

This is the second installment of a series dedicated to the molecular biology of the highly unusual and deadly turbo cancers (called hyperprogressive disease in medicine). In this episode, we look at how IgG4 can play a role by itself in cancer progression via its Fc stalk and its ability to interact with either other cancer-fighting IgG1 (and preventing their protective role) or by blocking immune cells from performing their protective roles. What we cover: *Cancer patients showed 11% IgG4 levels of total IgG antibodies in comparison to 3% in healthy subjects *IgG4 levels positively correlated with the stage of cancer *IgG4 level/total amount of IgG can be prognostic of cancer recurrence (past studies) *IgG4 is about 4X higher in cancer tissue than adjacent tissue *IgG4 can bind to anti-cancer IgG1 antibodies and inhibit their function *IgG4 does not have to target the cancer itself at all to help cancer growth *Co-injection of IgG4 of any type with cancer cells into mice always increases the tumor size/weight *It is the Fc stalk of IgG4 antibody that is responsible for its pro-tumor effects Location: Yamnusca Mountain, Alberta Described content: https://jitc.bmj.com/content/8/2/e000661 __________________________________________________________________ Dr. Raszek Credentials: https://merogenomics.ca/en/about/ ____________________________________________________________________ Please stay in touch with us on other social media channels: Twitter: https://twitter.com/merogenomics Facebook: https://www.facebook.com/unsupportedbrowser Blog: https://merogenomics.ca/blog/ Previously Microsoft was providing inappropriate warning about our newsletter sign up. If this happens again, there is an alternative option. Original Newsletter sign up (safe!): https://share.ebforms.com/5371824348594176 Alternate Newsletter sign up: https://merogenomics.us2.list-manage.com/subscribe?u=3d9e66f9296111f6b82215d5d&id=20ec19259e Instagram: https://www.facebook.com/unsupportedbrowser Patreon: https://www.patreon.com/merogenomics