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My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health. For an updated list of our current sponsors, please visit our website as previous sponsors mentioned in this podcast episode may no longer be affiliated with us: https://www. hubermanlab.com/sponsors Social & Website Instagram: https://www.facebook.com/unsupportedbrowser Threads: https://www.facebook.com/unsupportedbrowser Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/unsupportedbrowser TikTok: https://www.tiktok.com/@hubermanlab Website: https://www.hubermanlab.com/ Newsletter: https://www.hubermanlab.com/newsletter Apple Podcasts: https://podcasts.apple.com/us/podcast/huberman-lab/id1545953110 Spotify: https://open.spotify.com/show/79CkJF3UJTHFV8Dse3Oy0P Dr. Peter Attia Website: https://peterattiamd.com/ The Peter Attia Drive Podcast: https://peterattiamd.com/podcast Newsletter: https://peterattiamd.com/newsletter Twitter: https://twitter.com/PeterAttiaMD Instagram: https://www.facebook.com/unsupportedbrowser YouTube: https://www.youtube.com/c/PeterAttiaMD Facebook: https://www.facebook.com/unsupportedbrowser Articles Strength & longevity: https://peterattiamd.com/ama27 VO2 max & longevity: https://peterattiamd.com/how-does-vo2-max-correlate-with-longevity Timestamps 00:00:00 Assessing Health Status & Improving Vitality 00:02:51 Momentous Supplements 00:03:46 Thesis, InsideTracker, Helix Sleep 00:07:29 Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease” 00:11:51 Healthspan: Functional Testing, Cognitive & Emotional States 00:13:59 Blood Testing: Best Frequency 00:16:01 DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis 00:22:33 Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids 00:29:24 Osteopenia & Osteoporosis Diagnosis, Strength Training 00:31:03 AG1 (Athletic Greens) 00:32:16 Back-casting: Defining Your “Marginal Decade” 00:38:31 All-Cause Mortality: Smoking, Strength, VO2 max 00:44:43 Attia’s Rule of Supplementation, “Centenarian Decathlete” Physical Goals 00:49:24 Importance of Exercise, Brain Health, MET hours 00:55:23 Nicotine & Cognitive Focus 01:03:12 Menstruation, PMS & Menopause 01:10:10 Hormone Replacement Therapy, Menopause & Breast Cancer Risk 01:22:06 Estrogen, Progesterone & Testosterone Therapies in Women 01:26:35 Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin 01:37:23 Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG 01:47:46 Fadogia Agrestis, Supplements, Rapamycin 01:52:06 Testosterone Replacement Therapy & Fertility 01:59:26 Total Testosterone vs. Free Testosterone 02:02:51 Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B 02:17:42 Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions 02:25:15 Cardiovascular Disease, Age & Disease Risk 02:28:53 Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation 02:37:40 Metabolomics & Exercise 02:40:44 GLP-1 & Weight Loss 02:47:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com/ Disclaimer: https://www.hubermanlab.com/disclaimer