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In this episode, I explain the biology of hair, hair growth, why hair growth slows and what causes hair to stop growing and/or “fall out.” I discuss the essential role of hair stem cells and other supporting biological factors for healthy hair growth. Then I describe various approaches (mechanical and chemical) to slow hair loss by increasing blood flow to hair stem cells, including minoxidil, tadalafil, PRP, microneedling, Botox and ketoconazole treatments. I also discuss how age-related hormone changes cause hair loss and explain the effectiveness of treatments such as caffeine, saw palmetto, growth hormone, finasteride and dutasteride. For all hair growth options, I describe potential side effects, how soon to expect results and the amount of hair regrowth to expect and I highlight effective combination treatments for hair regrowth even in hair “dead” (bald) zones. For many listeners, thinning, brittle hair, or pattern baldness are a source of anxiety and stress. This episode explains the mechanisms underlying hair regrowth tools and the science behind them so that you can evaluate potential treatments and associated side-effect profiles and select the best one(s) for you. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Helix Sleep: https://www.eightsleep.com/eu/huberman/ HVMN: https://hvmn.com/huberman ROKA: https://roka.com/huberman LMNT: https://partners.drinklmnt.com/free-gift-with-purchase?rfsn=6327528.ecaabe8&rfsn_cn=EXCLUSIVE+GIFT+FOR+THE+HUBERMAN+LAB+COMMUNITY Supplements from Momentous https://www.livemomentous.com/huberman Social & Website Instagram: https://www.facebook.com/unsupportedbrowser Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/unsupportedbrowser LinkedIn: https://www.linkedin.com/in/andrew-hu.berman Website: https://www.hubermanlab.com/ Newsletter: https://www.hubermanlab.com/newsletter Articles Microneedling and Its Use in Hair Loss Disorders: A Systematic Review: https://link.springer.com/article/10.1007/s13555-021-00653-2?error=cookies_not_supported&code=137d0362-a991-47e3-b046-fc8812524603 Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review: https://karger.com/spp/article/33/3/153/296017/Caffeine-and-Its-Pharmacological-Benefits-in-the The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta-analysis: https://onlinelibrary.wiley.com/doi/10.1111/dth.13741 Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles in vitro: https://academic.oup.com/bjd/article-abstract/171/5/1031/6616284?redirectedFrom=fulltext&login=false The structure of people’s hair: https://peerj.com/articles/619/ Note: The Huberman Lab podcast has no affiliation with or financial benefit from any of the products listed below, which are provided as a useful reference only. Ketoconazole Shampoos Keeps: https://www.keeps.com/our-products/ketoconazole/0 Nurx: https://www.nurx.com/topical/ketoconazole-2-shampoo/fb/ Siena Health: https://www.sienahealth.com/product/ketoconazole-shampoo-2 Intelligent: https://intelligent.shop/products/intelligent-shampoo Biotin Shampoos Maple Holisitics: https://www.amazon.com/Biotin-Hair-Shampoo-Thinning-Moisturizing/dp/B01ENCBOA0 Ouai: https://theouai.com/collections/shampoo-conditioner/products/fine-hair-shampoo R+Co: https://www.randco.com/collections/dallas-collection/products/dallas-biotin-thickening-shampoo Microneedling https://www.amazon.com/s?k=microneedling+hair+2mm Timestamps 00:00:00 Hair 00:04:13 Sponsors: Helix Sleep, HVMN, ROKA 00:08:04 Psychological States & Hair 00:13:19 Hair Anatomy & Stem Cells 00:26:05 3 Phases of Hair Growth 00:35:40 Sponsor: AG1 (Athletic Greens) 00:36:55 Minoxidil & Blood Flow 00:45:37 Increase Blood Flow: Massage, Tadalafil, Platelet-Rich Plasma (PRP), Microneedling 00:56:10 Microneedling, Minoxidil & “Dead Zones” 01:00:13 Sponsor: LMNT 01:01:25 Botox Treatments 01:06:27 Androgens, Hair Growth & Pattern Hair Loss; Scalp vs. Beard Hair 01:15:46 Topical Caffeine & Slowing Hair Loss 01:21:06 IGF-1: Growth Hormone & Sermorelin; Insulin Sensitivity: Myo-Inositol 01:25:52 Iron & Hair Growth 01:27:04 5-Alpha Reductase & Saw Palmetto; Curcumin 01:33:22 Ketoconazole & Offsetting Hair Loss 01:38:46 Topical & Oral Finasteride 01:51:00 Post- Finasteride Syndrome 01:56:01 Dutasteride 01:58:53 Mechanical & Chemical Stimulation for Hair Growth 02:02:46 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com/ Disclaimer: https://www.hubermanlab.com/disclaimer