Descripción:
Subscribe to our channel: https://www.youtube.com/@optispan While scientific papers are generally considered trustworthy sources of information, it's important to approach them with a critical mindset and to avoid blindly accepting their claims. The peer-review process, which helps ensure high research quality, is not foolproof. Errors or biases can slip through the cracks. In reading a paper, we should independently evaluate the evidence, scrutinize the methodology, and reflect on alternative interpretations of the data. Considering the influence of funding sources, conflicts of interest, and the potential for selective reporting can also help in maintaining a healthy skepticism about new information. In this episode of Longevity This Week, Matt takes us through a recently-published paper about the effects of senolytic CAR T cell therapy on the aging process in mice to help us figure out whether the paper's claims hold water. He also analyzes a BBC article describing the findings. Popular press adaptations of the scientific literature often serve as a useful bridge between the complex world of research and the general public, but can be misleading in their attempts to make science accessible. They might, for example, inadvertently distort or oversimplify findings, exaggerate the significance of results, or selectively report research while ignoring contradictory or inconclusive evidence from other sources. We hope this episode will encourage viewers to approach science communication with a discerning eye, and to stay vigilant, curious, and open-minded in learning about the latest discoveries and developments. 0:00 Trailer 0:39 Introduction 2:11 Paper: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction 4:30 The paper's title 5:44 Going through the abstract 17:37 Does this intervention really improve health and delay aging? 18:32 Metabolic improvements 25:06 Exercise capacity 29:52 Other effects on aging 33:24 Possible takeaways from the paper 34:08 BBC article about the paper 42:22 Immune-based therapies to target aging 45:01 Translating these findings to humans 50:06 What's next on Longevity This Week Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!
Preparación de las opciones de carga
El sitio http://unidownloader.com/ es la mejor manera de descargar un vídeo o una pista de audio independiente sin necesidad de instalar programas ni extensiones.
La extensión UDL Helper es un práctico botón que se incrusta orgánicamente en los sitios YouTube, Instagram y OK.ru para descargar contenidos rápidamente.
UDL Client (para Windows) - la solución más potente que soporta más de 900 sitios web, redes sociales y sitios de alojamiento de vídeo, así como cualquier calidad de vídeo que está disponible en la origen.
UDL Lite - es una forma cómoda de acceder a un sitio web desde su dispositivo móvil. Con su ayuda puedes descargar fácilmente vídeos directamente a tu smartphone.
Los formatos de mejor calidad son FullHD (1080p), 2K (1440p), 4K (2160p) y 8K (4320p). Cuanto mayor sea la resolución de tu pantalla, mayor será la calidad del vídeo. Sin embargo, hay otros factores a tener en cuenta: la velocidad de descarga, la cantidad de espacio libre y el rendimiento del dispositivo durante la reproducción.
El navegador/ordenador no debería congelarse por completo. Si esto ocurre, por favor infórmenos con un enlace al vídeo. A veces los vídeos no pueden descargarse directamente en un formato adecuado, por lo que hemos añadido la posibilidad de convertir el archivo al formato deseado. En algunos casos, este proceso puede consumir recursos del ordenador.
Puedes descargar el vídeo a tu smartphone utilizando el sitio web de UDL Lite o la aplicación PWA. También es posible enviar un enlace de descarga mediante código QR utilizando la extensión UDL Helper.
La forma más conveniente es usar el UDL Client, que soporta la conversión de vídeos a formato MP3. En algunos casos, MP3 también puede ser descargado a través de la extensión UDL Helper.
Esta función está disponible en la extensión UDL Helper. Asegúrate de que la opción "Mostrar botón para guardar captura de pantalla del vídeo" está marcada en la configuración. Deberá aparecer un icono de cámara en la esquina inferior derecha del reproductor, a la izquierda del icono "Configuración". Al hacer clic en él, el fotograma actual del vídeo se guardará en su ordenador en formato JPEG.
Nada en absoluto. Nuestros servicios son totalmente gratuitos para todos los usuarios. No hay suscripciones PRO, ni restricciones en el número o la duración máxima de los vídeos descargados.