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00:00:12
good evening on air rub bathed science00:00:15
ready again today at the studio in00:00:17
visiting Alexander Nikolaevich Khokhlov00:00:19
Doctor of Biological Sciences Head00:00:21
sector evolutionary flowers gerontology00:00:23
Faculty of Biology, Moscow00:00:25
State University and Valery00:00:27
Mikhailovich Novoselov director she00:00:29
scientific mides scientific medical00:00:31
Gerontological Center and Chairman00:00:33
my gerontology sections at Moscow State University00:00:35
hello retail thank you very much00:00:38
that they came to our studio today and00:00:39
today we will talk about a topic that00:00:42
Well, exactly this is all about aging, we00:00:45
we are afraid of him, we experience how all this00:00:48
there will be someone who can and is not afraid today00:00:51
we will figure out how the mechanisms work00:00:53
aging and is it possible to prolong youth00:00:57
or gain immortality but according to tradition00:01:00
Before I start asking questions, let me remind you00:01:02
that you can ask your questions and I00:01:05
I will definitely ask our respected00:01:07
experts at the end of the broadcast also if00:01:11
want to ask questions out of turn00:01:12
send it to superchat it’s not there00:01:15
don't forget to subscribe to our channel and00:01:17
like so you don't miss ours00:01:19
new videos and send this link00:01:21
to your friends if you want them too00:01:23
joined this broadcast00:01:26
let's get down to questions and the first question is about00:01:29
what is aging in general, what are we00:01:31
we call it aging00:01:33
no one will start let's start with this00:01:37
was 35 years ago00:01:39
when I'm young Tkachev study aging00:01:42
I ended up as the captain's servant00:01:44
move Nikolai Khokhlov then worked00:01:46
the first thing he asked me was what it was00:01:49
aging that's how I remember '86 I'm young00:01:53
3rd year student of the Faculty of Medicine00:01:56
doctor who is interested in aging00:01:59
tried to explain to him stories about00:02:01
some mechanisms Perez Nikolay00:02:03
they say you know, you don’t need this basic thing00:02:06
definition of aging is decline00:02:08
vitality with age today00:02:11
35 years have passed and I believe that this00:02:15
the only correct definition00:02:16
aging the higher the age with the higher00:02:21
age, the more likely she is to die00:02:23
more is the correct definition00:02:26
exactly what is called essence00:02:29
aging daiso Nikolaevich yes I agree yes00:02:32
that is, I’ll just add low words00:02:34
that in principle this is all the right me00:02:36
said a little modified touch00:02:38
aging is a collection00:02:39
some age-related changes which00:02:42
leads to an increase, that is, not itself00:02:44
increase Russia totality of some00:02:46
age-related changes that lead to00:02:48
increased likelihood of death00:02:50
unfortunately the present moment is00:02:52
classic definition of which00:02:54
adhered to by all major authorities00:02:56
field of gerontology, but somehow00:02:58
ignored and00:03:04
very much mixed life extension00:03:08
not necessarily related to influence00:03:11
on aging because there is an ageless00:03:14
an animal that can also be extended00:03:16
life but you can shorten it in no way00:03:18
will be associated with aging and00:03:21
I have this in one of my articles00:03:23
picture00:03:25
where are the different survival curves written?00:03:28
what are the desire curves we take there00:03:29
let's say 100 animals and start at00:03:31
for several years, watch how00:03:34
they are dying out, we get such a prominent sigma00:03:37
the curve is the case of aging alive on00:03:39
bones ageless it will be exponential00:03:41
that is, which simply falls towards the axis00:03:43
abscissa and00:03:45
what is an exponent? is it when this one00:03:47
their rate of extinction is constant00:03:49
constantly this is not a straight line this is the name00:03:52
exponential constant speed but00:03:55
here in this article of mine there are several logs00:03:58
such exponent is the speed of death00:04:00
different exponents will also shift00:04:02
right left and00:04:04
gets your years to change and average00:04:06
continues to live as much as possible but00:04:08
there is no trace of aging here00:04:10
there is not aging so I would like00:04:12
this emphasizes what I was thinking00:04:14
Miharu agrees with me that in general00:04:16
prolongation of life is not always an effect on00:04:20
aging if some organism does not00:04:22
He's getting old, but you can extend his life00:04:25
there’s another moment here when he’s trying to00:04:28
definition down and means00:04:32
some mechanisms00:04:34
I believe, that00:04:35
the essence of aging is00:04:37
the mechanisms do in this case00:04:39
error why because lexan Nikolaich00:04:42
correctly said that today we are00:04:43
we don’t know the mechanisms or don’t know until00:04:46
end and when we make the definition00:04:49
mechanisms or any mechanisms in00:04:52
this concept then we get into a rut in00:04:55
rut of thinking from that scientist who00:04:58
leading this hypothesis is very dangerous00:05:01
the thing is a very dangerous thing because00:05:04
on aging from one of those great topics00:05:07
icons searched x-wing alexa nikolaich00:05:09
connected with continue life with that and00:05:12
longevity even has a theme of immortality00:05:14
such an interesting topic00:05:17
ageless animal lake addiction00:05:19
diseases are all a little different00:05:20
the topics are slightly different topics but this is not00:05:23
associated they are connected and very tightly00:05:25
connected but nevertheless even a topic00:05:27
biology of aging and biology sellers00:05:30
life is a little different things yes00:05:33
so when getting into the topic00:05:35
if there is any rut of thinking00:05:39
scientist or school means scientists00:05:42
gerontologists then we have here00:05:44
certain problem that we find ourselves in00:05:46
lavas of thinking of our lower thinking00:05:48
own thinking is dangerous00:05:50
thing there is such a theory that aging is00:05:54
disease as far as this theory00:05:56
justified, well, this topic will be found for a very long time00:05:59
almost a hundred years, which means I even have00:06:02
article00:06:04
success grant gerontology where00:06:07
comments further to my article 400:06:10
leading gerontologists of our country and not00:06:13
only our country00:06:14
means the topic of discussion is disease disease00:06:19
she doesn't have00:06:21
subject but because we are all different00:06:24
from a biologist's point of view00:06:26
the item is not worth it pours out like a rixa00:06:29
Nikolaychuk diseases disease for example00:06:32
the main thing is the world I lie down swordsmen means00:06:36
the founder of virtually modern00:06:38
Is gerontology all gerontology?00:06:40
it’s better that it’s your prayers Michael00:06:43
Zelman also believed that the disease was00:06:45
the main thing is not that he said it was a disease00:06:47
and what he said patton gelman chalk00:06:50
in view of the fact that these are mechanisms and for this00:06:53
wrote several monographs00:06:55
popular gave popular science and00:06:57
scientific and he proved that it’s yours00:07:00
disease mechanisms when they say today00:07:03
about connector diseases they say that it is over00:07:06
illness or super illness, well that’s also00:07:09
doesn't really make any sense00:07:11
discussions from a doctor's point of view and I00:07:14
still a doctor00:07:15
that means I can say against the creator00:07:18
that the problem here is not that the disease00:07:21
not the pains of aging about the very concept of illness00:07:25
concept painful not very not very00:07:27
such 1 ma can na I such but such00:07:30
amorphous there are three categories one of00:07:33
the Latin word for them is morbus, one of them00:07:35
dad pelvis and 3 but they are all on bail00:07:39
a little different in this situation00:07:41
when they say let's include it in the ICD and00:07:43
I was waiting for the classification of diseases and what it is00:07:46
will bring us some means streams00:07:48
financial this is not true because but in00:07:52
first doctors have something to do and00:07:54
recognize that all people are actually sick00:07:58
yeah but it doesn't make any sense and it's00:08:02
practical hand holding intervenes00:08:04
save so that doctors have something to eat00:08:05
do especially today like you00:08:07
you understand and in fact the quantity00:08:09
diseases associated with neither aging00:08:13
a huge number if for example we all00:08:16
we will deal with illnesses00:08:18
associated with aging then who will00:08:20
give birth00:08:22
treat teeth and so on, that is00:08:26
the range of doctors is very wide00:08:28
Today there are about 700 thousand doctors in Russia00:08:30
This is data from the Federal Statistics Service00:08:32
and I watched the recent ones, can you imagine?00:08:35
how many doctors there are and what they have to do00:08:38
to do by the way at the moment of starting00:08:41
the first war there were only twenty thousand00:08:44
21 thousand doctors and today 700,00000:08:46
very important topic for doctors and what to do00:08:49
A00:08:50
you said about gerontology what are the goals00:08:53
gerontology aims00:08:56
generally speaking, this is my favorite gerontologist00:09:02
this is alex comfort who wrote to everyone00:09:04
a wonderful book called00:09:06
biology of aging before in English she00:09:08
sounds and I'll start to translate it very00:09:10
it's difficult because there are two words00:09:12
denoting aging in English00:09:14
the sun itself aging here he has about these00:09:17
the words Narva do not appear, but our khans00:09:19
friends, the translation will sound on the road older00:09:21
so there he is00:09:22
said that gerontology is communication00:09:25
very correct name because00:09:27
translated from ancient languages means science00:09:30
O00:09:31
old people and in fact this is not science00:09:34
the old man's table as the science of aging00:09:36
how they become old and00:09:39
that's basically it00:09:42
gerontologist even study the mechanisms00:09:45
really aging but at the same time I00:09:48
I'm returning to my husband, we started needing00:09:50
understand what aging is00:09:52
That's why00:09:54
when we discuss with others00:09:57
gerontologists what aging is00:10:00
as a rule, even everyday life will ask a question00:10:02
what is gerontology what is it00:10:04
aging forever with such a famous00:10:06
gerontologist Aubrey De Gray Michael Know00:10:10
well it was even published there00:10:11
in the magazine means and when he was here00:10:16
there was such a party of us on Yakimanka and we00:10:20
they were discussing something there, games of eels, well00:10:23
after all, that’s what aging is and that’s it00:10:26
A00:10:27
that is, we gear long knows to grow old and00:10:29
what is the old man can this accumulation00:10:31
DNA damage00:10:33
I say [ __ ] it, it's a mechanism00:10:36
this is the mechanism and this is Mihai and the mechanism is you00:10:40
you say it’s a mechanism, but what is it?00:10:41
he didn’t give me a definition about aging00:10:43
understand, for now I'm our chairman00:10:44
the symposium did not say enough is enough00:10:46
no questions, he still thinks00:10:49
that the old days accumulate DNA damage00:10:50
separate you with gamma rays, you understand00:10:53
you are experiencing DNA damage I don’t know you00:10:56
immediately aged will launch of course00:10:58
radiation aging which00:11:00
really looks like a natural00:11:02
it's not aging itself so that's mine00:11:05
look I'm clear in my opinion in everyone00:11:07
different opinions on this matter, the ceiling even00:11:09
deal with fundamental mechanisms00:11:12
aging and00:11:14
it is possible to compare these mechanisms in00:11:18
different types, for example, and more00:11:21
Togo00:11:22
I have a very good relationship with00:11:25
download to the academician Petrovich and we00:11:28
we are getting old to argue souls, so to speak00:11:30
we have different views on these mechanisms00:11:34
also what is aging and so on00:11:36
so now he’s quoting what they say00:11:40
comfort it is written that it is impossible00:11:42
representing the cart and the horse getting old00:11:44
equally so I meant comfort00:11:47
that both age, but in different ways00:11:50
and Vadim Petrovich thinks that the cart is not00:11:53
gets old and only a horse gets old like me00:11:56
as it seemed to me so this is not00:11:58
absolutely so because most of all00:12:01
when I was the age you are00:12:04
now Alina me then00:12:07
also hoped for different carry00:12:10
respect I thought that would be all00:12:12
finance but we have financing00:12:15
it was very weak forever00:12:17
gerontology weak funded00:12:18
maybe we'll touch on it later maybe00:12:20
no but we are talking about what we are very00:12:23
The company has invested a lot in aging research00:12:26
mercedes-benz because they were interested00:12:29
how cars age00:12:32
they grow old very similar I must say and not00:12:34
you see, that’s because they’re curves00:12:37
survival yes they are described a little00:12:39
another curve there is much better00:12:41
fits not Gumpert's bull she's in00:12:43
principle and dialogues package them suites with00:12:46
the likelihood increases with age00:12:49
fatal breakdowns with higher mileage00:12:52
dirty for absolutely true breakdown00:12:54
you understand even if there is no mileage00:12:56
it's worth more than that I would say that we00:12:58
it's worth it in the garage, car owners know it00:13:01
more fluff more cartoon even stronger00:13:03
deteriorates from the fact that the tires are not standing00:13:05
scroll to it all that is in00:13:07
principle aging mechanisms therefore00:13:10
when they ask me this00:13:15
what is aging anyway?00:13:18
will withstand all the stars the planets are aging00:13:20
cars are getting old, getting old is another matter00:13:24
that living organisms have the ability00:13:26
they have reparation00:13:29
DNA they have regeneration of them and00:13:31
regeneration in some animals00:13:34
regeneration is absolutely super and can00:13:36
maybe we'll touch on it later when we're00:13:38
talk about the so-called immortals00:13:39
animals this regeneration allows them00:13:42
live almost indefinitely00:13:45
look I would like to add this thing00:13:47
here we are burning out and aging but somehow00:13:50
we have a very important word that is not00:13:52
It sounds like we're interested in aging specifically00:13:55
a person is not a horse, much less a cart00:13:59
namely the person therefore the listeners00:14:02
must understand that this is the word when00:14:04
doesn't sound, but still takes videos00:14:07
it is us who are the night people and we speak00:14:09
while on the street corner he appears to us on00:14:12
today we study aging as00:14:14
individual person means as separate00:14:17
animals as well as evolutionary00:14:18
there is gerontology general oncology00:14:20
such a subject means the more scientists00:14:23
connects now everything has piled up00:14:25
in bulk this is very important and maybe00:14:28
I call gerontology like a tiger that00:14:30
ready to jump, that is, only after00:14:32
the tip of the tail shows that the amount00:14:34
the accumulated data is so large that00:14:37
some kind of leap will happen although it00:14:40
expected quite a long time I hear00:14:42
the promise of a breakthrough since the early nineties00:14:46
remember there was such a Kurtzman book yes00:14:48
there let death disappear at the end of the line or00:14:51
after all, the early 90s and here I am every time00:14:53
such promises are made for 20-25 years, and so00:14:57
for today too, but for today00:14:59
there's a lot of data, that's just it00:15:01
For00:15:02
gerontology, here's one for the jump00:15:04
serious invoice already what it can00:15:07
to happen this is very important very important00:15:10
that's why in this situation I would like00:15:13
so that listeners understand what we are talking about00:15:15
aging and harmonic structure as a phenomenon00:15:18
phenomenon, this is a very interesting topic00:15:21
interesting topic but nevertheless that we00:15:22
didn't always take it at face value00:15:24
man, I wanted to ask about the mechanisms00:15:27
aging understand correctly what is here00:15:30
the difficult thing is that the mechanisms00:15:33
aging that seems obvious to us00:15:34
some markers of aging, that is, this00:15:36
there00:15:38
reduction in muscle mass you said00:15:41
there is radiation, what could all this be and00:15:46
not related to age a person can00:15:48
for example, experience stress and sit or00:15:51
well, there are some things with him00:15:52
occur not because of age but due to00:15:55
some other reasons and therefore these00:15:56
mechanisms we cannot unambiguously simply00:15:58
tie it to aging, well, you mentioned it00:16:01
markers where the marker and aging is00:16:03
famous thing is a big topic about00:16:06
but you understand biomarkers of aging can00:16:07
have nothing to do with the mechanisms00:16:10
sugoi biomarker of aging is something that00:16:13
correlates with age before starting00:16:15
costs to build sugar aviation curve00:16:17
so you know what the indicator is00:16:19
man you man you hulky see00:16:21
about a person says yes calm to00:16:24
unfortunately either Evans gays in detail about00:16:26
told this in one of his00:16:28
reports from our former chairman given00:16:31
to risk Moscow society so there00:16:34
many indicators of which or correlate00:16:36
with age and we usually see it has reached00:16:39
to the point of a man with a hunched gait00:16:42
dialing that it’s not his hands that are shaking00:16:45
you see, he has a lot of wrinkles and we00:16:47
we're burning, it's old, but everything's better00:16:50
the number of gray hairs correlates with properties00:16:53
hair that is 70,071 coefficient00:16:57
correlations that is, go toe mechanisms00:16:59
aging, by and large, is the essence00:17:03
therefore it has nothing to do with00:17:05
there is a gray-haired man maybe 30 years old and00:17:07
you look great make sunshine there00:17:08
generally 20 times on the horizontal bar at the same time00:17:11
maybe the check will be completely black00:17:13
beautiful hair at 70 and barely00:17:16
it walks, that is, and the mechanism is also something00:17:19
internal unfortunately definitely give00:17:21
none of us can answer this question00:17:23
doesn't know, it all depends on your worldview00:17:25
some scientists believe that the mechanism00:17:28
this is an accumulation of, for example, errors in00:17:31
genome yes what is the mechanism but00:17:35
you always need to understand in any theory00:17:37
aging00:17:38
there should be an explanation if there is one later00:17:40
maybe I'll just list the question00:17:42
to which my opinion should give00:17:43
the answer is any theory store and from this00:17:46
depends on how or the perception mechanism well00:17:51
DNA is a popular thing now, but it’s not00:17:55
definitely a lot now00:17:56
microbiota is doing a lot now00:17:58
engaged in microbiota return to the swordsman00:18:00
who did Mikhalych mention and in general00:18:03
microbiota is very important microbiota is00:18:05
collection of microorganisms that live00:18:07
in our gastrointestinal tract and00:18:11
Of course they influence this, is it possible?00:18:14
I always think it's a mechanism of aging00:18:16
I say, okay, how to be an animal?00:18:17
which do not have a gastrointestinal tract00:18:19
you see, they are different and how they are00:18:23
destroys grow old means accordingly00:18:25
how universal the concept is to me00:18:28
it seems that the aging mechanism that you00:18:31
postulates must be universal00:18:32
must explain the aging of any organism00:18:35
be it the simplest bacteria, so to speak00:18:38
This00:18:40
mammals and birds anyone here00:18:43
so that's up to today00:18:46
popular dish what to eat00:18:49
again, besides that, there’s still a mechanism00:18:53
on when that's how we invest00:18:55
concept of mechanism what really happens00:18:58
if we look at a car and say what kind00:18:59
aging mechanism here the engine can00:19:01
change tomoko and you can all together00:19:04
maybe all together or not00:19:07
it is possible that there is no single mechanism00:19:10
just a collection of different mechanisms00:19:13
such a very famous gerontologist00:19:15
verter who created the magazine00:19:17
experimental UAH dollars aka he in general00:19:19
I thought that DNA had nothing to do with it and that it was all about00:19:22
Kloden00:19:23
collagen, this tricky molecule means00:19:27
everyone says to write and so00:19:28
neurons here the child was born and he has00:19:31
neurons were formed one hundred and one hundred years ago00:19:34
the neurons are still the same, that is, the DNA in these00:19:37
neurons and00:19:38
120 and a hundred years yes means accordingly00:19:41
it seems like it's really a lot00:19:43
Do such molecules still exist?00:19:45
exists that's how you are since collagen00:19:47
can also live all these 100 years00:19:50
and here I am Santeria time for students often00:19:53
told you that you noticed that00:19:55
tattoo done by a very young person00:19:57
age persists until old age00:20:00
age order this paint for the most part00:20:03
sits on connective tissue, that is, on00:20:05
contact the same collagen and00:20:08
he explained how this happens when DNA00:20:10
The DNA story seems more logical to me00:20:13
because this is a matrix with which00:20:15
speaking, everything can be synthesized if DNA00:20:17
if not then you are still nothing00:20:19
snakes00:20:20
she he said that when collagen00:20:23
When aging, collagen molecule cross-links00:20:26
our Borzov dance gets something00:20:29
connect the fabric more and more shields00:20:32
tissue of the cell which it surrounds and there00:20:36
nutrients penetrate less well00:20:39
toxins are removed and therefore even then00:20:43
how the consequences may change and00:20:45
dna which comes first is like the chicken or the egg00:20:49
unfortunately, today I'm not here00:20:51
ready to answer what is primary and what is not00:20:56
It’s impossible that it’s another matter that there is00:21:00
now the followers called it that00:21:02
programmed aging and there00:21:04
a completely different programmed approach00:21:07
aging is a wasp example aging is00:21:09
implementation of the program in the body of which00:21:12
must definitely lead to aging00:21:15
Petrovich Skulachev is like ours00:21:16
classic programs are hosted00:21:18
that's why we00:21:20
they think that you were born in00:21:24
little girl then you grow up00:21:26
means in00:21:28
change and become interesting00:21:32
as a woman, yes, this means development, but for you00:21:35
but let's imagine what you have in mind00:21:37
not only a development program but also00:21:39
post-aging program and here it is00:21:43
Mikhail remembered Mikhalych's camp of [ __ ]00:21:46
for the sake of their teachers with great00:21:49
treated him with respect, we saw each other00:21:51
him for the last time not long ago and at death's door00:21:53
New York when he lived there and now in00:21:58
in general, its concept is close to me because00:22:02
that he was basically a doctor, he was there00:22:05
female god in St. Petersburg and in general he00:22:07
a woman made an appointment with him in three00:22:09
months at the reception he knew a lot but00:22:11
he had some q to carry00:22:14
several whales and tone due to aging00:22:18
oncology pregnancy he is very many00:22:21
I found interesting things there and00:22:24
here and there and there and he tried to tie00:22:26
believed that development works like this00:22:29
way00:22:30
there is a concept00:22:33
Williams antagonistic pleo therapy00:22:36
which means that the principle is the same00:22:38
principle, that is, you have development00:22:40
goes a certain way for you00:22:41
there are certain prizes they need00:22:43
in order to get a proper divorce, but00:22:45
then unfortunately they start working00:22:47
wrong and they make you sick00:22:51
otherwise it’s impossible it’s a necessity therefore00:22:55
this is the implementation of a development program but00:22:58
carry her after the fact, that is, when she00:23:00
no longer necessary, this is not what it suggests00:23:03
our programmers are like what we call them00:23:05
program, you think it is embedded in the genome00:23:08
what you have there, not only how you00:23:10
you will develop and as you continue to age00:23:13
you're starting to get old by the way store00:23:17
starts 14 15 years old that's why00:23:19
the definition that we gave our Michal00:23:22
than just inconspicuous, she’s not00:23:25
very noticeable yes but nothing at all00:23:28
note in gerontology needs to be removed00:23:31
survival curve and here's the curves00:23:33
the survival of these teenagers is us00:23:35
live, we have data, let’s say00:23:37
registry office there is a death certificate00:23:39
birth before you can look at these00:23:41
all the data and take a look and you will see that00:23:43
the probability of death before age 15 is not00:23:47
is changing, that is, although she will notice very much00:23:51
many changes in development00:23:53
a teenager has a lot to organize00:23:55
changes in age-related changes yes00:23:57
it increases less but not at all00:23:58
affects the probability of death up to 14 1500:24:02
years and then and that’s why I’m not very good00:24:05
I like Vadim and Gladysheva's concept00:24:07
who believes that aging begins00:24:09
immediately after birth I rudely tim00:24:12
look, well, you yourself come to00:24:14
these bars are where your probability is00:24:17
of death00:24:18
begins to grow only after 15 years of age00:24:22
what you leave started earlier here for00:24:24
This phrase makes no sense to me because00:24:26
if if it is more likely to increase as needed00:24:29
flies away aging no there are changes but00:24:32
after 15 years it begins to increase00:24:35
rice and this look I’m very happy about what’s next00:24:37
the faster it goes that the famous one discovered00:24:40
recruited all of us gerontologists for the competition00:24:42
that it is possible that death is growing00:24:44
exponentially00:24:45
that is, at great speed00:24:48
picking up but at first it's still the same00:24:51
this is the same exponent as it first goes00:24:53
almost parallel to the x-axis and then00:24:55
she just accelerates and00:24:57
so I’ll add more pain, I’ll add it00:25:00
yes, pay attention, that's what it means00:25:03
raise any gerontologists at night00:25:06
this topic of what aging is will be for you00:25:09
talk for 2-3 hours and it will be very interesting00:25:11
interesting things means I would like00:25:14
add what what00:25:16
the essence still appears to us here what what00:25:19
we are not cells, tissues or organs, we are00:25:22
means much more than the sum that is00:25:26
we are not even the sum of all this together00:25:27
taken and much more and this00:25:30
much more this is integrative00:25:31
this is the setting between all this where00:25:35
Causality is very difficult00:25:37
keep track of 2 essential characteristics00:25:39
It’s possible that the criteria are from the trailer00:25:42
It's worth adding some more00:25:44
additional criteria when there is gi00:25:46
please tell me more about the criterion from the trailer00:25:48
Then00:25:49
and dagennost means the trailer is one of00:25:53
gerontologists00:25:55
which is written by one known00:25:59
relying on books from which I also studied00:26:01
unfortunately we don't have a textbook for00:26:03
There is no lymphology yet, but there’s more to it00:26:05
we're working and here's a book of comfort up to00:26:08
biology biology of aging and from the trailer00:26:11
cell aging time can be considered here00:26:13
First of all, they are not the main bases00:26:16
engaged in compilation this is primeval00:26:19
the thought is even more so in Alpatov’s translation00:26:20
is the founder of sex and gerontology00:26:23
which were created 50 years after year00:26:26
Institute of Gerontology00:26:27
there are four cooling towers there, that means00:26:29
acceleration has signs of00:26:33
gradual destructiveness00:26:35
endogeneity and something else there was some00:26:38
fourth sign of reliability00:26:40
gradualism in general00:26:42
versatility versatility means00:26:45
everything seems to be clear here, all these except00:26:48
endogeneity here I am endogeneity00:26:51
I consider it an acceleration00:26:54
will arise in any case under the most00:26:58
favorable cash conditions00:27:00
good health that's how I am00:27:02
I am considering this criterion all tops00:27:05
looks at it a little differently but00:27:07
nevertheless I look so much at the trailer00:27:09
translation conclusion yes of course but00:27:13
[music]00:27:15
Here00:27:16
means to me Perry is talking about what00:27:19
the fact that these mechanisms are built-in00:27:23
physiologically in all our00:27:24
physiological reactions metabolism00:27:26
epigenetic changes and specifically00:27:29
so with this age dependence00:27:31
diseases are not related to aging mechanisms yet00:27:34
signs of cascade steal are observed00:27:36
it means it's very hard to understand00:27:39
it is clear that is the reason that00:27:41
is a consequence but just Nikolai00:27:43
stuffed animals went very far volume markers00:27:46
very far from where it all started00:27:49
I would like to make a small remark that00:27:51
have or until lined with markers again00:27:55
there was talk about a Mercedes in the car00:27:58
garage there are two options first00:28:00
biomarker if we take an hour and electronic00:28:04
on the wall, then in one case as a biomarker00:28:06
and what are the arrows00:28:07
or there are consequences00:28:11
batteries or should it show00:28:13
the battery charge is some kind of juicy00:28:15
I think the battery is low00:28:17
this is what you see, these are different things00:28:19
the marker is basically what it shows us00:28:21
shows how old the topic is by the way00:28:24
Sanka las said the topic correctly00:28:26
markers and means hours before and00:28:31
biological age since now00:28:33
wrote the whole world Kozlovsky age this00:28:36
very interesting topic on it there 40000:28:39
the sign of this is not the volume endless00:28:41
this topic can be discussed for a very long time and00:28:43
write very interesting books here00:28:46
so as you noticed, it means any00:28:49
Grant LGA was asked about one thing and he was very00:28:51
will talk for a long time and very00:28:52
interesting things are very noses00:28:54
feature m and she captivates in goes along00:28:56
life00:28:59
noticeably about biological age as00:29:02
since you said I00:29:05
about this question what is this00:29:07
biological age and00:29:09
this person only has something00:29:12
a person can look just like you00:29:14
it seems like this for more years00:29:16
some kind of social thing because we00:29:18
an animal can't look like you00:29:20
answer why your cathedral dog has them00:29:23
Weston you can tell what a puppy is up to00:29:27
but when it became overgrown I didn’t ask anymore00:29:29
take a guy you rarely see00:29:31
for example perch00:29:33
will download about my house by the way00:29:37
300 feature when you're trying00:29:39
Determine age just stay 105 years00:29:41
which you rarely visit, we are there too00:29:44
you'll get things done earlier, not because00:29:46
you see, we are operating now00:29:48
social concepts about look she00:29:50
looks like 30 to urgently looks like 3000:29:54
let's try to understand what it is00:29:56
means not actually talos tag00:29:58
no no left my house it's the same00:30:01
what do the experimenters you mentioned do00:30:04
two good books there are two more good ones00:30:06
review book 1 taxes aging00:30:09
arian lamb which we also learned that00:30:12
there is also an absolutely wonderful book00:30:14
and the introduction of the experimental Gerd Loge00:30:16
which was written by Tamara Lvovna Dubina00:30:19
Morovna treated me very well and00:30:23
the last copy of the book with deed of gift00:30:24
I have it and that’s how it is about HIV00:30:28
yes, yes, yes, well, we wrote the cudgel00:30:30
we understand he was the director of the place00:30:33
that's why the age struck ten there00:30:36
everything is actually told when we00:30:38
we look at a person and determine whether we will00:30:40
what we do we figure it out in our own way00:30:42
experience if you ask a little one00:30:45
child who survived all the time00:30:46
isolation and how old is this aunt?00:30:49
won't say anything he has no idea00:30:51
you have collected a large number of markers00:30:53
you see the wrinkles the gray gait00:30:57
fat not fat hunched over not00:31:00
hunched over, yes that means teeth are very00:31:03
good indicator for teeth and eyes skin00:31:06
everything from the skin is a very good indicator yes00:31:08
and it’s understandable why because00:31:10
skin elasticity changes collagen as00:31:12
times but you don’t measure anything and you00:31:15
instantly take a photo of a person in your home00:31:19
in the brain in which hundreds of parameters you00:31:22
rate and choose the ladies he looks like00:31:24
forty but you compared it with what00:31:28
Muscovites who are usually public00:31:30
and if you look at the Vietnamese there00:31:33
a woman in her 60s can look like ours00:31:35
40 they are so smooth skin and they are00:31:38
here they have another low mechanism00:31:40
aging, although in principle long-lasting00:31:42
their lives00:31:43
not fundamentally different from ours but00:31:46
they do it all differently and00:31:47
smarter and different therefore biological00:31:50
age is a certain thing, you and I, Mikhail, than00:31:53
this is already discussed this is some kind of virtual00:31:55
the value is tied to that population00:31:57
on which you made00:31:59
calibration and how is calibration done?00:32:03
took the mice00:32:04
of different ages and according to them but00:32:08
let's say the number of hairs of fur there00:32:10
per square centimeter00:32:12
and put this number of hairs aside00:32:15
the ordinate axis and the abscissa axis you will have00:32:18
age you will get a kind of straight curve00:32:21
this could be the best anyway00:32:23
these are straight because it's easier to count00:32:25
although I have options for other curves00:32:29
so you got some kind of false00:32:32
curve and then you take the mouse00:32:34
the age you want to give in00:32:35
in your case, you take the dog, yes, with00:32:38
which you picked it up somewhere00:32:40
you got in the end you don’t know how much00:32:41
how to determine you we are now taking here00:32:46
these hairs you take from her hairs00:32:48
count hairs on a square00:32:49
centimeter and on that curve which00:32:52
got you find the point00:32:54
corresponding to this number00:32:57
number of hairs and then go down00:32:59
on the x-axis and get the age here00:33:02
he is her and his biological age is in no way00:33:03
not related to her passport age00:33:05
so if a person is 70 and he looks00:33:09
on 30 what does this mean for example that it00:33:12
the skin corresponds in terms of the number of wrinkles00:33:15
on average on average00:33:17
means the skin of a 30-year-old man, but this is00:33:21
these conditions where you filmed these00:33:24
calibration curves are also the same00:33:27
animals you can do biochemical00:33:28
analyzes like this are ideally the more00:33:32
the parameter you took is00:33:36
multiple model is given that00:33:38
biologists calculating from the cards in which you00:33:40
build00:33:42
independence is simply y from x and you have00:33:45
that means there are a lot of players, that is, you have a lot00:33:49
different indicators, that is, you can00:33:51
let's say some blood counts there00:33:55
indicators00:33:57
lung volume up to the value, well, let’s say it was00:34:00
this English test didn't burn00:34:02
biological growth was 1200:34:04
physiological tests and all that x00:34:06
died then determined that's Bill Gates00:34:09
speed on them for why then what00:34:11
first they are on the control population00:34:13
built calibration curves therefore00:34:16
absolute value of biological00:34:18
age does not exist he is tied who and00:34:20
population for which you built the curve00:34:23
here we can add that the assessment is external00:34:26
score it should be accurate I'm pretty accurate00:34:29
but first of all it depends on the lighting00:34:31
depends on the amount of makeup00:34:33
interventions in cosmetic surgery00:34:35
procedures and we train her, for example00:34:38
pediatricians here I mean talk otherwise00:34:41
I estimate the age of my children with accuracy00:34:43
up to six months a00:34:45
criminologists by the teeth it’s by appearance00:34:49
I mean, for example, evaluate people over 8000:34:52
years with an accuracy of three years00:34:54
this is important and I will do more on the children00:34:57
error please note that children00:34:59
who study at school you studied at school00:35:01
you clearly defined what00:35:03
this boy he and 7 eyes here and here you go00:35:08
it was hard to determine your age00:35:10
when you taught school but some kind00:35:12
repeater and who stayed for five years00:35:14
there he looked just like you00:35:17
achieved well yes and it turns out that what00:35:22
with your age you also change here00:35:26
this means your grades change too00:35:29
it is correspondingly more accurate00:35:31
age groups and which are more or less00:35:33
close to you and yet we train it00:35:36
and very accurately assessed by people who00:35:39
work with people00:35:40
police officials00:35:43
it means with this it would be very00:35:46
interesting stories that can be found here00:35:48
means to tell as fables00:35:50
when people reached their age later00:35:53
they me and their places of residence names and00:35:56
and accordingly they didn't look very good00:35:58
young such cases in history were in00:36:00
shadows lexa nikolich said it right00:36:01
this means this is a sample where00:36:05
buble there would be a woman written on it00:36:07
there was a sample for 50 years it doesn’t exist00:36:09
there are two interesting things I do very much00:36:12
there are a lot of mistakes now growing up woman00:36:14
35 to 55 because00:36:18
it's gorgeous in the external state00:36:22
woman means modern00:36:24
women are associated with cosmetology this potion00:36:26
colony dog 2 1 but this can’t be00:36:29
connected because there percent and bad00:36:31
happens to a person very quickly00:36:32
evolve strangely enough, here is the report00:36:35
16 years old00:36:37
VAZOVSKY WORLD ZATIONS INJURY00:36:39
aging means and health means there00:36:43
it was noted that today there is a lot00:36:45
people of the age you are very00:36:48
good quality they are in good quality00:36:50
physical and mental and many people with00:36:54
Now Moscow is doing everything for this00:36:57
so that people are healthy once in their lifetime and00:36:59
often when a person runs from behind or00:37:01
on a bicycle in sportswear and00:37:03
age is difficult to determine, he is in good condition00:37:05
functional state my my grades00:37:08
that in today's population here I am00:37:12
I remember my father changing since 191200:37:14
at my age of 60 it was00:37:18
living man he was already tired00:37:21
past front, that is, he came00:37:24
home I sat down I rested I come00:37:27
home I run I go the gym completely00:37:31
different status you understand, yes, that is00:37:33
we are changing not only we are changing ours00:37:36
environment and past life always00:37:38
this connection between the external environment and its changes00:37:42
the person himself the person changed the environment and00:37:45
today he decided to take up the light of joy00:37:47
life00:37:48
in his own way it turns out that in this00:37:52
situations of really aging, as it were00:37:54
moves away, that is, some kind00:37:57
processes occur there, but at the same time00:38:00
what ordinary people are used to calling00:38:02
she really does move as she gets older00:38:04
because from active age00:38:06
it spills almost there until00:38:09
infinity I'm afraid that's not true00:38:12
because very sister good good00:38:14
know these people die very early too00:38:17
professional athletes00:38:19
they are well pumped up you can see they are00:38:22
so many problems with joints and heart00:38:25
such yes, excuse me, the drive wings with00:38:28
trailer there is a criterion of gradualness here00:38:30
I categorically disagree with him, the point is00:38:33
that aging progresses differently00:38:35
it connects with external factors in00:38:38
including diseases and injuries, it can00:38:40
speed up means you can do00:38:42
means a person can come to 000:38:44
vitality means and make him00:38:47
the pacemaker will be brought in00:38:50
surgery will put stands for him and he will00:38:53
still live twenty years what has changed00:38:56
changed viability there and00:38:58
the main thing is that the possibilities of society have changed00:39:00
to support her maintaining me when well I00:39:04
started traveling to the states in ninety-one00:39:06
year and here I am in ninety-four00:39:09
year when I was in the hospital there00:39:12
I spent quite a long time in Kansas and then often00:39:15
I told the students and you understand I say00:39:17
complexity life expectancy and what00:39:19
you think life is here I go into this00:39:21
hospital and00:39:23
I want to get into the elevator and it’s right behind me00:39:26
here are the thorn points often00:39:29
I think this is a doctor's appointment00:39:33
an old lady who looks like she's at least a hundred years old00:39:34
but she's sitting in a chair with00:39:37
a bunch of devices attached to it00:39:39
chair and tubes and wires go to it and00:39:43
she will live like this for another 20 years, life is00:39:46
or not, well, in general, we support life00:39:49
a very long life in some Sparta00:39:52
and you understand that the night is just right there00:39:54
since everyone removed such people and here we live00:39:57
so here is the life expectancy in00:39:59
in our society it is still important00:40:01
quality of life therefore00:40:04
was known at the Institute of Gerontology00:40:06
Kiev which unfortunately is now to00:40:08
we don't care about this, you should say it00:40:11
add00:40:12
life years they years life00:40:15
this is how life should be00:40:18
full-fledged, but these people who can00:40:21
look beautiful we see as if00:40:23
movie actress she has suspenders yes she has00:40:25
carry everything but she's completely sick I'm00:40:27
completely ill and we find out that she00:40:30
died there at the age of 55 from cancer00:40:32
you see, it didn’t help unfortunately00:40:34
therefore the internal mechanism is external00:40:37
view does not affect00:40:38
by the way, this is an interesting topic00:40:41
This means that this report also states that00:40:43
here's an increase in life and here's not much00:40:46
closely related to quality of life00:40:48
concepts health by the way concept00:40:50
Health in old age is a special topic here00:40:54
why this theme of aging disease disease00:40:56
new ones constantly arise00:40:59
discussions have been going on since the escape a hundred years already and00:41:01
constantly flares up and there is a discussion00:41:04
there are disputes about what is being washed away00:41:07
visible old people and does it really look like00:41:11
health00:41:12
you see that's what I always say00:41:15
look people in the morning your not me when00:41:17
there are discounts they usually apply here you go00:41:20
breasts on the trolley why because00:41:22
triangle two legs and a cart yes it is00:41:25
the most stable figure they are looking for a point00:41:27
of course there was a support point in them00:41:29
alex they are kalach profane they would be in00:41:31
conditions of Sparta or wild forest recently00:41:33
only society would have died00:41:36
society modern developed society00:41:39
the humane society makes this possible00:41:41
live for people and bring them joy00:41:43
loved ones and of course the main task00:41:46
gerontology is not only an increase in00:41:47
of life to increase the quality of life in this00:41:50
the report just says that00:41:52
that's from the point of view00:41:55
doctors' observations are not very good00:42:00
it is connected that we did not live better then00:42:02
There is00:42:03
disability this is happening this00:42:05
age that's why it's very important00:42:08
moment that we00:42:11
began to live no longer in all periods00:42:15
life or only in youth or only00:42:17
saw lastly in all of the period we became00:42:20
live longer due to old age00:42:21
this is a period in the infirmity of illness and00:42:24
dependencies there is another tricky thing00:42:28
which when I was very young me00:42:30
Surin drew my attention to her00:42:32
from my efforts Professor Berdyshev from00:42:34
Kyiv that's when we say00:42:36
centenarians until gave gaap husky only00:42:39
how long do they live, that's by the way00:42:42
a separate story with Georgian00:42:43
centenarians hey flick and medvedev00:42:45
wrote great articles about this00:42:47
in fact, everything is not so and you said00:42:50
about and in the passport and forgery of passports yes00:42:52
didn’t want to go there one atom and most importantly00:42:55
wanted to go to the First World War00:42:57
during the war they made themselves a separate passport00:42:59
According to him, their housing there is 30 years older00:43:02
and with such a beard we don’t know black00:43:04
how many years are there under it? yes that's why it's00:43:07
same question but00:43:09
basically00:43:12
Means00:43:14
to be this athlete of all sorts of fundamental00:43:18
Unfortunately, mechanization is such a topic that00:43:21
introduces roles in captivity, yes, I just want to00:43:23
centenarians started therefore centenarians00:43:26
There are two options for creating long-livers00:43:29
the first one is really something like this00:43:31
these blue zones and where are they00:43:33
really good eat well00:43:35
they live and you think they last very little00:43:37
stress because he is a husky type00:43:39
long-liver when we went to Abkhazia00:43:42
this positive and look at all of us00:43:43
saw to catch these which is surrounded00:43:46
veneration and he has 40 relatives and00:43:48
we are young girls washing our feet, he is sitting00:43:51
you understand, it means it will fall apart and bring it to me00:43:54
I then she immediately runs, you know00:43:56
he lives comfortably with him00:43:58
no stress, another option is from the mountains00:44:03
centenarian from the Altai Mountains00:44:05
that's where the situation is completely00:44:07
the opposite and refusal of Berdyshev and00:44:09
drew my attention to the fact that00:44:11
there are long-livers there00:44:13
live the lives of their brothers and sisters that00:44:16
it turned out to be the nineteenth century00:44:19
the family is a very poor poor family in which00:44:23
there is nothing they give birth to 20 children one at a time00:44:26
others 19 die but it's the same00:44:29
combinatorics we understand that every time00:44:31
her brothers and sister look different00:44:33
because two with genetic lost00:44:35
is combined and in the end it00:44:37
manages to bungle a child like this00:44:41
which all these misfortunes can survive00:44:43
and from such adapted and00:44:45
this population of centenarians arose00:44:47
actually live the lives of their brothers and00:44:50
sisters because if I can say00:44:52
natural selection even a little bit00:44:54
pages survives the risk it00:44:56
actually artificial even selection00:44:58
you know, that's what they said about wild00:45:01
nature and of course in the wild after all00:45:03
everything is different too, here are the sparrows00:45:05
how long do sparrows live? They live up to three00:45:08
years old child in the wild and up to 21 years old in00:45:11
captivity means, well, the conditions are expensive00:45:14
and by the way they don’t grow old there they don’t00:45:16
they manage to arrange the goods at the tomb00:45:19
saying they don't live to see 15 like strays00:45:21
dogs are also like stray dogs that00:45:23
V00:45:25
the dogs are very strong, these are the pack00:45:27
stray dogs they are like this00:45:30
it means that no one can, these were00:45:32
hour because we have defenders who00:45:34
they're walking around protecting me, so I think they're00:45:36
can survive very many people in general00:45:39
saying yes there is a special base00:45:42
for animals ask for life because00:45:45
very interesting things everyone thinks to me that00:45:47
he lives for three hundred years, no, he's a thief00:45:50
nature there is up to 15 years old and it is only 6000:45:52
years ago, and chimpanzees, for example, are in this database00:45:55
otherwise called00:45:57
match this chimpanzee 59 4 recorded00:46:01
Charlie is 74 years old, how long have I been there?00:46:04
you mean00:46:06
Tarzan the ape no this is it00:46:09
this help them ponzi who lived00:46:11
I smoked cigars there for a very long time00:46:14
Are you interviewed by famous people there?00:46:16
the database there is less than 60, this is confirmed00:46:20
because we understand that all00:46:21
hollywood changes she lived with one of the00:46:24
there are some people just great Ryazan00:46:27
it is unique to communicate and communicate as00:46:30
no more wait you know what00:46:33
gorillas have their own language, they just don't00:46:34
can speak they don't have a voice00:46:36
apparatus but also the language of communication is quite enough00:46:38
developed with gorillas in general it is possible00:46:40
communicate completely without gestures when00:46:43
I observed monkeys in the wild00:46:46
conditions in different African countries and I love00:46:48
very africa visit on the border in00:46:51
the camera is no closer to the Central African one00:46:53
republic there is a nursery for00:46:54
chimpanzee I talked to the French00:46:57
who work there they said that00:46:59
they heard that where on about this base00:47:01
they talked they said what they heard00:47:03
that somewhere a chimpanzee lived there for 65 years00:47:05
but this is a female and there is very decrepit and00:47:08
not verified but continues like this00:47:11
this is what we were behind this chimpanzee00:47:13
the plot is almost leaving he was filming00:47:16
in some films for you, as I understand it00:47:18
Why don't people over 30 live in00:47:21
in nature they will occupy themselves and eat and00:47:24
I can’t help but ask about animals here00:47:27
who don't age at all00:47:29
what kind of animal is this?00:47:32
separate topic I don’t know Risa Nikolaich00:47:34
will start because I'm very happy about it00:47:35
I wear myself critically as if I’m ageless00:47:38
I don't know that mortality rates change with00:47:41
age up to but there is a concept of ontogenesis00:47:44
that is, most mammals do not00:47:46
maybe she can't serve in one00:47:48
state of the concept of individual00:47:50
development00:47:51
the animal must develop, grow and give00:47:55
posterity it calls for change00:47:57
parameters that will come included00:47:59
reproductive function, respectively, and00:48:02
bringing forth offspring, so to speak00:48:05
such animals that do not age and do not00:48:07
curve ageless she is the same00:48:10
mortality rate is the same throughout life00:48:12
and by the way, sometimes negative aging00:48:15
such a very rare term, for example00:48:17
in crocodiles their size decreases with age00:48:19
aging and what a mikhalycha I saw on the field00:48:22
that is, two types of ageless animals00:48:25
two types which are the first to die00:48:27
exponential00:48:28
mayfly number lives one day before us but00:48:31
she won't drink herself to death, but this will be staged00:48:34
exponent and the second option is those with00:48:36
survival curve horizontal that is00:48:38
don't die at all and then without00:48:39
attachments for freshwater hydra hydra00:48:42
dies mostly of course she doesn't00:48:44
grows old in this given understanding but00:48:46
dies from others scream if she00:48:49
create ideal00:48:50
she will live forever yes at least00:48:54
here is this article by jones which is known in00:48:56
the evening that came out and which I am discussing00:48:59
in his article which is called00:49:00
immortal hydra. again it means there00:49:05
that means they calculated theoretically according to00:49:08
at least 1460 years she could00:49:10
live, give them punishment, Caleb has00:49:14
Finch led no idea was aging yes00:49:17
that is, it is invisible and should not be installed00:49:20
of course all these turtles and bowheads00:49:23
whale who are there 2 caught a female wing00:49:26
monastery 211 years old00:49:28
that means 211 years as you determined00:49:32
probably read on00:49:33
left right form of amino acid in the eye00:49:36
what is it determined by the ratio?00:49:38
yes that means00:49:41
yes it's a lot but of course they don't care00:49:45
store only slowly very slowly00:49:47
so there are some, but there are hydro ones00:49:50
some other species are similar00:49:52
they really are not coelenterates and00:49:55
store why can I tell you this?00:49:57
I have already written and talked about this a lot00:50:00
you see, we mentioned export at the beginning in00:50:04
this is a very correct thing we00:50:06
integral beings we exist in00:50:08
form of the system and in general is very important to us00:50:12
personality and individuality00:50:13
so tell them car car00:50:16
you can repair as much as you can generally speaking00:50:18
change everything and there is nothing in this car00:50:21
remains from the original you have something wrong00:50:24
the situation is not the same for all of us00:50:26
so we have non-replaceable ones00:50:29
replaceable cells up to00:50:31
brain neurons I can't00:50:35
change cardiomyocytes, well, practically00:50:38
you can't eat don't take a heart transplant with00:50:41
all the problems associated with the invasion00:50:43
and so on00:50:44
liver is almost impossible, that is, we have very00:50:48
many so-called post-methodical00:50:50
If cells don't divide, you can't replace hydra00:50:53
took a different path she has no00:50:56
individuals are not individuals00:50:57
Animals have individuality00:51:00
I have no personality, although I myself have many pledges00:51:02
don't agree read they have personalities00:51:04
maybe they're right00:51:06
two employee believes that her cat00:51:08
she was the realest person00:51:10
there are times I perceive as having left00:51:12
his member is Galya you can understand but00:51:16
Yes, I think a lot of people are dog lovers00:51:19
touches do not agree with this would be yes but that00:51:23
no less in principle they have00:51:24
they can remember the experience but you00:51:27
you can’t even replace these animals00:51:29
all cells hydra changes everything she went to00:51:32
you way she has the so-called aes00:51:36
l100 there are such, it’s an analogue of stem ones00:51:38
cells that multiply all the time00:51:42
a.s. and where is the bar from immoral times?00:51:45
her dad is a hydra and she has all the tentacles00:51:49
time the old cells listen, that is00:51:51
it flows like this all the time00:51:53
updated completely and within a few minutes00:51:54
days it may not be updated completely00:51:56
there will be no glue left I ask00:51:59
I'll just give her brains and she has brains00:52:00
they don’t have any as such and there are several00:52:02
neurons that perform certain00:52:04
functions it reacts there if you00:52:06
say goodbye is shortened and so on if00:52:09
you will land in perfect perfect00:52:11
conditions, that is, you will be fed and watered and00:52:13
remove germs and feed her there00:52:16
the rains of which with well00:52:18
here's Martin from00:52:21
not long ago I made you read an article00:52:24
this one he's been trying for years00:52:25
supported the hydra so much indeed00:52:27
death did not change they did not die00:52:29
another thing is that this is how she lives in00:52:32
determined only by temperature conditions00:52:34
and then she doesn't have sex00:52:37
reproduction, unlike humans00:52:41
sex is harmful, you know, started and00:52:44
if she doesn't have sex00:52:46
reproduction just gets dirty and00:52:48
so she can live indefinitely00:52:51
Then00:52:52
Now if the temperature in this body of water00:52:55
she changed and became uncomfortable00:52:58
will block sexual reproduction so that00:53:00
complete decomposition these essences00:53:03
which00:53:04
stem cells they turn into00:53:06
sexual and begin to give sexual00:53:10
reproduction starts new ones appear00:53:12
individuals but at the same time she cannot herself00:53:14
update that is, this is her board with00:53:17
that's right, that's the price to pay00:53:19
you understand reproduction and actually00:53:21
when they say that a person does not have00:53:24
immortality in a certain sense is you00:53:26
remember the sex cells that00:53:28
pass from generation to generation00:53:31
he wrote to me a lot about this and it was very00:53:33
This is an interesting topic and he recently died00:53:36
in the heat of Solis our Medvedev who I am very00:53:38
I had a lot of respect for her, in general I can say with00:53:41
which were already seen here in Russia when00:53:43
he came back here for a few of my yes and00:53:45
zombie time so he wrote that he00:53:49
wonderful review on this sex00:53:52
the line is infected, that is, it still weighs00:53:54
noted that there are infinite immortals00:53:56
germ of the phenomenon in you allen live cells00:54:00
your parents and so on in the cage00:54:03
in and how are your cells up to your station00:54:05
for children, in a certain sense, this is00:54:07
such an immortal line of germ cells00:54:10
which flow but personality00:54:13
unfortunately I don't have any individuality here00:54:15
I know I think the lines are just a line because00:54:18
that it ages everything in our body00:54:20
most likely all cells including germ cells00:54:24
this is very important, we just listened00:54:26
transfer pass skills an error was made00:54:28
It is said that sex cells do not age00:54:30
everyone grows old and without exception this00:54:33
very important and rice oksana cleanliness00:54:36
drawing kalach dedicated to the memory of fats00:54:38
sex started bra bra three video and00:54:41
founder of the heart of gerontology whole00:54:44
the seventh year of which I organized this00:54:45
here is the scientific community which00:54:47
there are which I am heading now00:54:49
it's written here and explained clearly00:54:51
that's why we are then born to my00:54:54
young, but nevertheless the cells are still00:54:56
grow old, yes of course and therefore sexually00:54:59
cells of course age from here and when00:55:02
when they say oh you know in the germ cells00:55:04
There is telomerase, yes, that’s what they are there00:55:07
but the telomeres didn’t say it there, but I00:55:09
I think that if necessary we can talk00:55:10
this is the enzyme that allows00:55:13
the same cancer cells for example00:55:15
exist indefinitely again00:55:17
not to not but not specific cells but00:55:19
populations of cancer cells beautiful00:55:22
Perry North to forty in the summer00:55:24
percent will go away and die just every time00:55:27
moved but overall the population is therefore00:55:29
if people are classified as a population but00:55:30
also hydra, yes you see, endlessly00:55:33
reproduces and everything that concerns00:55:35
germ cells, yes, and in men and in00:55:38
women's situation is completely different00:55:41
a girl was born from her reproductive cells00:55:45
somewhere around 300-400 thousand she has more and more00:55:50
she's not afraid of anything new, she'll be theirs00:55:52
spend what is it this is a week00:55:55
developing this is the culture on which00:55:57
works in my laboratory we work on00:56:00
week, the entire cell is thereby modeled00:56:02
aging of cells that's how they are00:56:04
gradually00:56:05
gives what it means to swim00:56:09
years old not only not an old man00:56:11
it is known that the older the woman, the00:56:14
she is more likely to appear00:56:16
operant offspring yes it's something like that00:56:18
associated with accumulated mutations where in00:56:20
germ cells head cell receives00:56:23
what does it mean to punish but let's00:56:25
they say we’ll make sure that these mutations00:56:28
sex cells not a bit, I say well00:56:31
let's pretend you'll do this00:56:34
you thereby completely00:56:36
evolution evolution lives on change00:56:39
sex cells because there will be no food00:56:41
Generally changes look all over here we are00:56:44
all living things were removed by changes in00:56:46
germ cells00:56:47
they did absolutely no treason at all00:56:49
evolution became so and why because00:56:52
it seems that it will be even better00:56:53
quality population that is due to what00:56:56
Allen changes his appearance otherwise we have00:56:59
gradually [music]00:57:01
mutations occur mutations in the reproductive organs00:57:03
cells and gradually due to00:57:05
combinatorics of mutation there at the very least00:57:08
from a frog you get a lizard and want00:57:11
when I was still studying at the Faculty of Biology00:57:13
they said that actually I’ll be there now00:57:15
say things that can actually happen00:57:17
will be received with pleasure by believers00:57:19
people because basically without00:57:21
interference of something here is the game transition00:57:23
from frog to lizard imagine without00:57:26
attracting higher intelligence is impossible00:57:30
because if I need a little00:57:32
her paws begin to change, she can’t help but00:57:35
jump no crawl at me until instantly00:57:38
should turn into something so to speak00:57:40
from jumping to crawling from this00:57:43
you need something like several hundred mutations00:57:46
certain probability I'll dash off00:57:49
the probability of occurrence of which is well00:57:51
the truth is almost zero, well that’s how it is00:57:52
evolution works this way but if00:57:55
You00:57:56
prohibit any changes in germ cells00:57:58
then never if the cat doesn’t have a lizard00:58:00
it will work out00:58:01
pay attention xo don't say saying00:58:03
about hydra he said that if they change00:58:05
Any conditions and weather conditions mainly00:58:09
climatically this means this means00:58:13
mortality of this means polyp it00:58:18
tied to the seasons00:58:20
here I wanted to draw your attention to the fact that00:58:24
There are animals that don't live long00:58:28
they can aging and ageless from00:58:31
where they live a lot they can grow old00:58:34
don't grow old it's a form of temporary00:58:37
design of a specific type specifically00:58:40
type of specific environmental conditions00:58:43
if we change the environment I will give the case of hydride00:58:46
everything a person has done changes everything for us00:58:56
And00:58:57
hello again please excuse us00:59:00
there were some minor technical problems but00:59:02
now we're back again00:59:05
I hope we don’t go too far00:59:08
Let's continue our conversation about aging00:59:12
[music]00:59:14
I wanted to go then00:59:18
talked about what is00:59:21
life and what we consider to be00:59:26
the very life that stands like this00:59:28
I can’t continue as much as possible here00:59:30
don't ask about gear tread what is it00:59:33
this and what prospects do they have?00:59:38
well again it all depends on the point of view00:59:42
means researcher00:59:44
I would have said earlier that what Herbart00:59:47
what warms up is maximum00:59:50
life expectancy because a00:59:52
after all, a lot of people cook it, so we invented it00:59:56
our new gera protector is medium00:59:57
life expectancy of animals is sure00:59:59
that 15 percent, well then the best01:00:03
hero protector these are antibiotics01:00:05
you know, do you know when they appeared01:00:07
antibiotics naturally life changed01:00:09
but I’m in my lectures when even the biofield01:00:12
zira they and many really liked this01:00:15
picture where two curves were shown01:00:17
survival01:00:19
one thing means these are rats that don’t want water01:00:21
given at all and to others who were given01:00:25
so those who died without water01:00:27
immediately and those who were given water lived01:00:30
happily ever after01:00:31
can the input be considered a tread hole?01:00:33
no, that means we still have to share01:00:36
and here accordingly therefore and with01:00:40
to continue life as much as possible01:00:42
very difficult01:00:45
how to conduct experiments on this in01:00:48
principle01:00:49
you can come up with one of the changes when01:00:52
a substance that in fact is not01:00:54
affects aging but it01:00:58
increase maximum duration01:01:00
life is still the definition of such a hero01:01:03
protector is what it is01:01:04
slows down aging01:01:07
that is, it slows down, but when you have average01:01:11
continues it immediately slows down01:01:13
aging is another matter what then later01:01:15
when she gets there it's called01:01:19
rectangular rezation curve survival01:01:21
when it started it takes a long time01:01:23
horizontally in that claps collapses01:01:24
down but like a mayfly01:01:27
it means nothing has moved maximum01:01:29
then yes it will be slow at first and01:01:31
slowly and aging and then suddenly and in01:01:34
on average it will of course be high everything01:01:36
therefore, it’s clear to say right away01:01:39
I don't have such a definition01:01:41
today but there is one more01:01:43
here's a trick I recently published01:01:46
article called choosing01:01:47
control objects d diameter01:01:49
logical research is very tricky01:01:53
thing because there is a lot now01:01:54
Hera protector appeared01:01:56
followed by animals and01:01:59
animals are taken for a reason and in this01:02:02
in the article I even considered in detail the experience and01:02:05
Makey, maybe you've heard of this01:02:07
scientist Clive Mackay in the 30s he was01:02:10
was the first to discover that the limitation01:02:12
nutrition01:02:14
slows down aging01:02:15
animals01:02:17
aside what he did he took the rats there and in01:02:22
basically that means his rats were fisher01:02:26
34401:02:28
such a line creed and he01:02:32
control01:02:34
they sang and ate as usual01:02:37
he reduced the diet of the experienced01:02:40
why do I say actually restrictions01:02:43
power supply for Gera Protector tablet yes01:02:45
many of today's hera protectors are01:02:48
Memetics of food restriction are very01:02:51
many there metformin er about Amy price01:02:53
resveratrol there they are all of them and many01:02:57
act like you also limit01:02:59
nutrition so look what happened01:03:02
he chose these rats and really01:03:04
they lasted both average and maximum01:03:06
lifespan of only one01:03:08
subtle point we have already talked about01:03:09
it's time to look wild and then if you take the wild one01:03:12
these rats look like cats are non-linear01:03:15
mice and those that come straight from nature01:03:17
taken they are taken out and a clean line to them01:03:19
Bradley when crossing long close01:03:22
closely related mice receive clean01:03:23
all of them they are all the same in this01:03:25
advantage of linear mice take decks01:03:28
they live longer than their maximum lifespan01:03:31
those rats are the first second01:03:35
these fish rats 344 very high frequency01:03:39
development of spontaneous tumors and01:03:44
if food restriction is overwhelming for you01:03:47
carcinogen from the site and ending it like this01:03:49
that's why they lived, does it affect01:03:51
old again, we treat diseases01:03:53
at the beginning we said this is a disease or01:03:55
not a disease no it's probably not a disease01:03:57
aging but if you treat diseases then01:03:59
the body will live longer and the person01:04:01
animal you can't talk here01:04:05
the fact that they really have rs and 3 more 301:04:09
such a moment that animals in01:04:12
experiments on kerry fed from01:04:14
libitum it means they ate the thing01:04:16
as much as they wanted, that is, from the belly in nature01:04:19
there is no such01:04:21
Animals in nature usually go hungry01:04:24
so this is not normal for them and01:04:26
maybe that's why they lived less01:04:28
what should about but those who with01:04:32
food restriction was just what they ate01:04:34
ok yes there are three more models very01:04:38
popular for which they work01:04:40
gerontologists and on whom it tests01:04:42
Hera protectors for example are mice itself01:04:46
css or rated mouse, that is, it is a mouse with01:04:49
accelerated aging and01:04:52
the Japanese did it back in the seventies01:04:55
this mouse here and there there are two lines 1 himself01:05:00
p and another himself p here is a quote about them01:05:05
means prone to accelerated aging a p01:05:08
it's resistant01:05:10
accelerated aging and then they did it alone01:05:13
control and other experienced but then in01:05:16
all the experiments that were carried out in01:05:18
including from us in Russia they took it here01:05:21
these samps, that is, they were already with01:05:24
defects and what through the defect and they01:05:26
there are a lot of problems including01:05:29
generation of free radicals when they01:05:31
they were given antioxidants and they felt better01:05:33
the best or what kind of hero protector01:05:35
danger protectorate just medicine they01:05:37
treated sick control mice01:05:40
take away pure control we still have01:05:43
mice in common with which there are also problems01:05:46
with the generation of free radicals in them01:05:49
oxidative stress is very strong and01:05:52
these mice axis in general means yes too01:05:56
if you give them01:05:58
antioxidants they live longer well01:06:00
actually after that wait and more01:06:03
one very interesting model is this one01:06:06
the same ones are published all over the world01:06:07
for some reason no one pays attention01:06:08
called Swedish mice they are bred01:06:11
Sweden they also have a mitochondrial defect01:06:14
dna polymerase01:06:16
which enzyme is in mitochondria01:06:18
which you need is normal01:06:19
functioning of mitochondria mitochondria01:06:21
This01:06:22
energy carry the stove where we have01:06:24
all energy is produced and ATP is formed01:06:27
And01:06:29
since their a is broken with01:06:32
the functioning of their mitochondria01:06:33
a lot of free radicals01:06:35
gave flax yield directed01:06:38
antioxidant and it prolongs life01:06:42
I asked, I say, what about wild mice?01:06:45
oh no but we haven't done that yet yes that means01:06:48
well that's why the protector hero is that01:06:51
what slows down aging01:06:55
another thing is that everyone puts everything into it01:06:57
different and01:06:59
here again the main word of which01:07:02
not here, we are interested in mountains01:07:04
human human protector undoubtedly01:07:07
in this situation Alisonka is only correct01:07:09
said increase consider it a protector then01:07:12
that increase the maximum will continue from01:07:14
human life, well, what is this topic?01:07:17
the simplest possible life for a person if01:07:19
take the records, they are very dubious01:07:22
dubious the thing is that for today01:07:24
all the people who are super centenarians01:07:26
older 110 115 years old they were all born in01:07:30
the period when they were not exactly exactly01:07:33
butt clamp births were possibilities01:07:35
document changes the entire 20th century is a century01:07:38
wars people changed strange place01:07:41
their residences and even strangely disappeared and01:07:45
reappeared01:07:46
By the way, I wonder what01:07:49
when they studied centenarians01:07:53
North American United States01:07:54
that's what it used to be called in the USA01:07:57
Russian literature in Russian01:07:59
literature there were identified 201:08:01
interesting fact that01:08:03
African American centenarians or like us01:08:06
we understand that these are not actually slaves01:08:10
there were slaves they were illiterate in them01:08:13
google centenarians and much more but01:08:15
there was another category where long-livers01:08:18
it was hundreds of times more01:08:20
migrants are those who moved from Europe01:08:22
moved and01:08:25
Here01:08:28
Frenkel Frenkel these are books this is the 20s01:08:31
for years it has been mentioned that01:08:33
citizens of Poland or the Russian Empire01:08:36
former ones were among them hundreds of times01:08:38
more centenarians therefore heroes01:08:41
protector I understand that it can be recognized01:08:44
and water and that means a normal lifestyle01:08:46
antibiotic year protector but in general01:08:48
can we take a marker and a marker we can't01:08:53
take people from birth to give metformin01:08:55
some category of people so that they all01:08:58
life is the most important thing why in public01:09:00
view of 120 years to remove survival curves01:09:03
you understand you have decided you have come up with01:09:05
cool hero protector and even if you01:09:07
By the way, the ethics committee did not allow01:09:09
I'll allow you to work on this in public01:09:12
impossible we don't allow such things01:09:15
experiments but even if you allowed01:09:17
this stage would take one hundred and twenty years01:09:19
only on one curve for firstly they01:09:21
the researchers themselves did not live that long01:09:23
had to change several times01:09:25
longest longest studies01:09:28
has been following you since '3901:09:31
four groups took turns to explore this01:09:33
it was to watch or on and then when01:09:34
took boys from wealthy families and01:09:37
needy families and throughout life01:09:39
it means you looked at what you carry, it depends01:09:42
life takes some indicators01:09:44
biochemical, sometimes known, sometimes not01:09:46
no real research is being done in01:09:48
girls at the university and in Leipzig01:09:50
his time was spent in. General01:09:52
no trace, that is, when not to compare01:09:54
people of different ages who shared01:09:56
everyone takes one cat at different times01:09:58
cohort mascara people born at the same time01:10:00
and they are being watched there for 30 40 years, it’s scary01:10:03
expensive very difficult but very successful01:10:06
important results it is very important that01:10:09
does not study exactly the same people01:10:11
different people born in different countries01:10:14
different conditions, respectively, in different01:10:16
different times but that means we have this option01:10:19
we throw it away because it's01:10:22
expensive and01:10:23
pull rene force then or mihal01:10:26
so that I don't forget in these studies01:10:28
generally transverse and longitudinal surveillance01:10:31
transverse when we took different01:10:33
people's ages and measured this one01:10:35
big shortcomings here are Catholic01:10:38
the research was still going on while Leipzig was01:10:40
means in that Germany in this and there01:10:44
rose to an interesting dream amazing01:10:47
the thing I remember all the time01:10:48
We usually say that with age01:10:50
the amount of cholesterol rises to01:10:52
that this is kind of bad why would they say01:10:54
because they took old people at least from01:10:56
they got a lot of cholesterol01:10:58
they have few hobbies erase tied01:11:00
according to the state that impudent01:11:02
Wednesdays and what did they do in Leipzig01:11:05
noticed that those who have a lot01:11:07
cholesterol they live longer swelling01:11:09
lost cholesterol they die earlier01:11:12
so arzan gradually in this01:11:14
big in these 25 thousand people01:11:17
the number of people with small children has decreased01:11:21
amount of duster on a chick but01:11:23
cholesterol they survived it turned out01:11:25
light up a 90-year-old cat, relatively speaking01:11:27
yes, there are many more people with elevated01:11:30
cholesterol because x sheet us01:11:32
You definitely need this cholesterol01:11:35
Soviet times were keep traders01:11:37
eggs that stood with the boxes you01:11:39
no longer remember, but we still remember when01:11:40
There were such women standing in the streets and selling01:11:43
eggs a bowl of large boxes they have a block01:11:45
there were balls of battle, that is, that’s what they didn’t01:11:47
they could sell it to a bank of 100 say01:11:50
broke it and then drank it all and so on01:11:52
every day 5 6 10 and driving nothing01:11:56
felt fine01:11:57
you understand, that is, along the spike of the membrane01:11:59
build new cells build without01:12:01
then you can't sirin so it's not very good01:12:03
a difficult question with cholesterol here01:12:06
transverse and do not give much trace01:12:09
mistakes and based on them01:12:12
gerontology for known reasons01:12:13
which were Mikhail, what did he already mention?01:12:15
You can’t rely on individuality to make all discoveries01:12:18
last hundred years on cross money01:12:20
built and also such a tricky thing as01:12:23
differential mortality is what it's about01:12:26
I suck memory 0 and there is also a secular trend01:12:28
A01:12:30
what is a secular trend too01:12:32
amazing thing look01:12:35
here in Belgium a job has appeared in which01:12:38
analyzed head size01:12:40
Belgian men there and they did01:12:43
the conclusion is that with age this is acceptable01:12:46
let's say the size decreases there01:12:49
cross-sectional studies, that is, they01:12:51
they took the leader, they had height, but the older they were01:12:53
those01:12:54
let's say below, but in fact it turned out01:12:58
something that is simply gradually due to01:13:00
acceleration treason these are all born with01:13:03
large size01:13:04
heads understand they themselves they have them01:13:08
larger nucleation size but since those01:13:10
people who are 50 now were born 50 years old01:13:13
ago you remember yes that knights01:13:15
medieval they are about fifty meters there01:13:17
60 meters of latex given something01:13:19
small doesn't mean that's why she01:13:22
if you compare them not because Nikita01:13:25
age-related changes are called01:13:26
secular trend, that is, it is associated with01:13:28
such evolutionary changes01:13:31
human population temporary and in01:13:33
We don’t catch this client’s habit01:13:35
that's why he's not the guide01:13:37
actually yes this is the only one01:13:39
more or less reliable way to gerand01:13:41
logical research but unfortunately01:13:43
you imagine exploring there01:13:45
a huge number of people throughout01:13:47
for many years not everyone is disciplined01:13:50
they come to get examined, they lose many01:13:53
not because they didn’t know how, they were just tired01:13:54
walk and so on, although they even paid01:13:56
for this and all that's why she's here01:14:00
undoubtedly the topic is this research this01:14:04
separately science by sciences 3 is separate01:14:07
topic of a person I never think that there can be a lot01:14:08
what to say on the topic, including these01:14:11
research onions ideal and cuts it01:14:13
but if you go back to the markers yes01:14:16
that's exactly the gear protection, we can take it01:14:22
conditionally, which not only slows down aging01:14:25
because this is a difficult concept, but also01:14:27
For example01:14:30
will delay the development of age dependent01:14:33
diseases are cheaper more01:14:35
short follow when we take the group01:14:37
5055 people already have souls we are looking at01:14:40
biomarkers yes even if I'm gray and01:14:43
I dyed my hair like01:14:46
it will be amazing and you will do the same01:14:48
solution to color what to eat in old age01:14:51
clinical design, that is, the disease and01:14:53
internet syndrome we take two groups of 10001:14:57
man alone takes some kind of hera01:14:58
protector we look at who had it first01:15:01
the faces of the church are not the same or not, that is01:15:04
this is the first then the second slowdown01:15:06
joining 2 age dependent01:15:08
diseases, the thing is that in age01:15:10
we hang and diseases they steadily01:15:12
Here's the main feature that arises:01:15:14
people die but today in developed01:15:17
countries depending on age01:15:18
this is the peculiarity of diseases01:15:20
if we slow down01:15:22
we slow down joining 2 if at the same time01:15:26
our skeletal condition is also improving01:15:28
interfering muscles decrease01:15:30
dependence on help01:15:34
cognitive deterioration slows down01:15:36
functions hours should in part of patients01:15:38
coronavirus and almost everyone in one or01:15:42
in a different form means what if I find01:15:44
there will be medicine and mind and if I start01:15:46
only coronavirus, here's your dad01:15:49
for everyone it will become and will improve for everyone01:15:51
conditions and note coronavirus01:15:53
there are many consequences there and they are easy01:15:54
both the heart and blood vessels are affected and will begin01:15:57
things are getting better, we can assume that we are01:15:59
affected by aging I believe that on this01:16:02
the question cannot be answered because it is a virus01:16:04
human immunodeficiency HIV is01:16:07
you also understand that people have been sick for decades01:16:10
and they are constantly getting worse01:16:12
her condition worsens from the track01:16:14
progresses01:16:16
immunodeficiency can say correctly01:16:18
that they are getting old01:16:20
because of this I think that the difference between01:16:22
at today's level we cannot do this, but01:16:24
this is my opinion fingers they are of course01:16:26
There are certainly some conventions, but01:16:28
nevertheless an exogenous cause01:16:30
the emergence of new environmental factors01:16:32
coronavirus yes, but still it’s a little01:16:35
so they are not directly related01:16:38
that it beats the mechanisms of aging in what01:16:40
It’s strange that he can run for example01:16:42
yes, but today she has many rantala01:16:45
generators say that yes01:16:47
aging processes associated clinical01:16:48
symptoms or begins to rot and01:16:51
a lot of environmental violations01:16:52
By the way, it’s interesting that there are planks too01:16:54
think a huge number of neurological01:16:57
violations01:16:58
all situations what passing immunity01:17:01
immunity virus hits specific01:17:04
pathophysiological mechanisms and it hits01:17:06
at the intersection of carbohydrate metabolism and oxygen01:17:09
homeostasis is strange headquarters ato01:17:11
physiologists have not heard pathophysiology01:17:13
heard by KHC and taxes by epidemiologists01:17:15
bioinformatics is heard but people are not heard01:17:18
who work with mechanisms and he beats01:17:20
specifically these people with type 2 diabetes01:17:22
with hypertension means with01:17:25
committing oxygen minus01:17:26
endothelial dysfunction that's what01:17:28
leads to the junction of these two01:17:30
low diseases this is very important but01:17:33
it is an external environmental factor01:17:36
that Wednesday was the first thing I noticed that01:17:40
we population has grown older and therefore01:17:44
what if we take it 100 years ago this was the world01:17:46
young people01:17:48
the population was almost 5 times greater01:17:50
less there was one there a hundred years ago01:17:52
one out of 7 billion population it was01:17:54
world of young people in an overcoat with a rifle on01:17:58
leaving the war world where did it go01:18:00
spanish flu virus when not01:18:03
knew that this was a different world01:18:05
another01:18:07
mortality other gender and age01:18:09
the pyramid is perfect for today01:18:12
we have become old and the process will be01:18:14
growing up is very important because01:18:17
will grow old will grow old and not01:18:18
there will just be aggression top spa aging01:18:21
populations have become popular that is01:18:24
this must be clearly distinguished; this is not aging01:18:26
separately by population aging average01:18:29
age and generally speaking this is considered01:18:31
that this is good because if people01:18:33
live long it will be planted when I get old01:18:35
populations and what’s more, the signs are simply01:18:38
aging to population and connectivity01:18:41
decrepitude decrepitude is clinical01:18:43
syndrome senile asthenia syndrome01:18:45
not just people they are huge01:18:49
socio-economic burden there01:18:51
agarron orc is not Gaddafi's word01:18:53
There are a lot of developed countries in the EU01:18:55
people who are 90 years old, they are all retired01:18:59
they live on what they earn01:19:01
if you have 30 percent of the population01:19:04
pensioners, they need to be fed, watered and01:19:06
allow them to travel abroad01:19:08
trips by the way are a gift as they are by 210001:19:11
Japan is about to lose its population01:19:13
repetition associated with up populations01:19:15
will lose 40 million population at01:19:17
population equal to our country there are 120 of them01:19:19
million is a little different but they are01:19:22
the essence and of these remaining 80 million01:19:24
half will be over 60 years old from 50 ohm01:19:27
twenty-nine years later01:19:29
the number of people over 60 years of age will be01:19:31
2 billion, that is, can you imagine?01:19:34
these are the approaches to old age already sixty01:19:37
years, at least today there is such a concept01:19:38
as young people this is probably a lot01:19:40
really people and this group in general01:19:42
elderly people from 60 to 74 she is very01:19:45
unevenly today because people01:19:47
it has become a lot, which means the language requires new ones01:19:50
colors and probably some new ones01:19:52
old age classifications01:19:53
old age long-livers what01:19:56
it all looks very different01:19:58
of course a person 60 65 years old and and there 707501:20:02
especially the mobile field with a man01:20:04
pathologies are different things, that's why01:20:07
returning again to the world of patronage01:20:10
today we can say what if01:20:13
functional state improves01:20:17
Dependence decreases and moves away01:20:20
age dependent diseases up to01:20:22
Accordingly, we are talking about the fact that01:20:24
quality of life means and disease is a thing01:20:27
In general, this disease was previously called01:20:29
suffering, that is, a component of suffering01:20:31
goes away if we move it more01:20:34
late in life this can be sent to them01:20:35
there is nowhere to recognize the coat of arms as a protector01:20:37
human that we understand us01:20:39
I'm not interested in the hydra, not the naked mole rat, but01:20:42
this is the man that is very important01:20:44
aging is always the theme of a person01:20:48
the fact that gerontologists are physicists, chemists and01:20:51
biophysicists biologists cytologists there01:20:54
in fact, doctors don't have it very much01:20:56
great sadness here we are today01:20:57
We are trying to rectify the situation and write01:21:00
textbook on the basics of gerontology which01:21:02
there has never been a country where doctors01:21:05
today it’s realistic that the majority01:21:08
population and01:21:10
most patients, doctors are people01:21:12
age age so they don't know01:21:15
only geriatrics but gerontology then01:21:18
again the basis for neretve and01:21:21
would it be correct to say that in this01:21:23
in the context of gear, protectors are01:21:25
not even just some direct substances01:21:28
how much of a way of life in general01:21:30
which allows you to move it, name it01:21:33
This is a gear with tread impact01:21:35
let's just say yes, although you understand that01:21:38
you allow physical activity01:21:39
food before me they all ask01:21:42
say, well, how is it possible now?01:21:45
live longer that's it and that's me01:21:47
I say yes you can but you don't want to01:21:50
we don't want you to come in and you don't want to01:21:53
one understand that's when I would completely01:21:55
young I knew a girl01:21:57
very pretty means which and conversations01:22:00
for gas you already wrote it there01:22:02
chemistry life article about what is harmful01:22:04
how harmful is it to sunbathe? It’s very01:22:06
burning harmful american magazines all01:22:08
were clogged with cancer hanging to the logical01:22:11
the magazine always published on the cover01:22:13
there about us sunbathing only in01:22:16
these metal things01:22:18
which cover me almost entirely yes01:22:20
it means that everything was reflected somewhere01:22:22
listen, you want me to go white01:22:24
no one will look at me like a caterpillar yes01:22:26
I'd rather die at 50 we live we01:22:29
we want we don't want to live long we want to live01:22:31
ok, by the way, I’m exactly the same, you know01:22:34
here I am nocturnal in mind yes to me01:22:36
for example a night to work more01:22:38
comfortable but not understood not useful01:22:40
probably for me you understand and wavy01:22:43
dinner in the evening is not healthy and cosmetics are not01:22:46
we have to use it, we want to live so that01:22:49
it was nice01:22:51
if she fantasizes for example01:22:54
a little bit and imagine that we01:22:56
we can somehow defeat aging01:22:59
physical does this mean that we will become01:23:01
immortal01:23:03
these are completely different topics01:23:05
no unfortunately no this is considered01:23:08
called Michal, we also know we’ll take it01:23:10
if we are on this curve then what?01:23:12
is our drag curve aging she01:23:15
consists of background mortality and that's it01:23:18
holiness associated with age it is possible01:23:21
isolate that is, you have01:23:24
mortality is due to causes not01:23:26
related to aging me a brick fell from01:23:29
roofs you understand yes the car you understand01:23:33
some serious illness, also HIV01:23:37
for example yes this is the reason these are all the reasons01:23:40
not related so if you subtract everything01:23:43
you will get everything related to aging01:23:46
the survival curve of a person who is not01:23:49
gets old and you get that average later01:23:51
there will be no life for seven hundred 800 years01:23:53
that's it and when do I need to dry it?01:23:57
that's cool, I remember the interview in Israel01:24:00
gave Israeli television some01:24:01
listen but this is cool01:24:04
700 and drying in general is the same question01:24:07
the article says I say no and I don't01:24:08
I agree, imagine this01:24:11
woman speak listen to me only 70001:24:12
years old and I should already be dead, I’m nothing yet01:24:16
I haven’t seen I haven’t been on Mars haven’t eaten haven’t01:24:19
was to understand this as possible I am only 70001:24:21
he lived for years, he gets used to it very quickly01:24:23
when the average duration was 2001:24:25
people lived this long before they ate them01:24:28
all the time until and now we live at 70 8001:24:32
seems to be young so we will stew01:24:34
to live even 234 it will still not be enough01:24:37
but unfortunately yes, that is, if you01:24:39
get rid of aging completely, you all01:24:42
you will still be limited like this01:24:44
called background mortality but01:24:46
which you cannot regulate01:24:47
fell like a meteorite, understand I'm more cheerful01:24:51
man that's why I agree to live and 70001:24:53
800 so that’s not it and that’s where it comes from by the way01:24:56
taken and it's you and according to time01:24:59
color quality is not necessary to do and01:25:01
people are physiological monsters01:25:04
so that the quality of life corresponds to this01:25:06
request01:25:08
the quality of life should be high01:25:11
so you need to figure out exactly what01:25:13
we talk about the mechanism after we need it01:25:15
to understand the mechanisms is precisely in01:25:17
these gear mechanisms when or01:25:19
pairs of worms or unclear01:25:21
cause-effect in this lies01:25:23
then somewhere, by the way, where are these 500 from?01:25:26
years that the British Aubrey Dee promises01:25:28
Gray, they are probably from these calculations01:25:31
calculations there are from 500 to 700 years old, but here they are01:25:35
yes indeed if it stays like this01:25:36
How about 20 years of viability?01:25:40
living like this for so long, but01:25:42
there is for this you need to work and not01:25:44
forget about the consequences of social01:25:46
always just good data to01:25:49
endured the angle not only of overpopulation01:25:52
one of his latest articles01:25:53
wrote, just imagine going out to01:25:55
you will never become a house at all01:25:57
because it means you understand you are the boss01:26:00
he’s young, he’s only 600 years old, which means01:26:04
all positions of the daughter in this laboratory assistant you01:26:06
laboratory technician for 300 years01:26:08
are released instead of at the expense of01:26:10
why academician feel his01:26:12
people die and become academics yes01:26:14
she says you won't have it01:26:16
some other no eggs Nikolaich two01:26:19
the question here reduces into one was not transferred01:26:21
it is another01:26:23
even if it’s not enough, you add them all01:26:25
took their seats and no dwarf01:26:28
You simply won’t have any career growth.01:26:30
because for some reason you are all here now01:26:32
yes you you and you are not getting old you carry01:26:36
sheriff and your boss doesn’t age, but he01:26:38
500 years old and he's a USA guy, I'm like a cucumber01:26:41
I think the blood is all gone we haven't touched01:26:43
a very important question that is probably not01:26:45
This psychology is within our competence01:26:47
aging because we not only age01:26:50
physically getting older mentally you understand and01:26:53
mentality of an 80 year old man even if01:26:56
during the day they say oh my grandfather is 80 years old01:26:59
Gotoh years old doing pull-ups on the horizontal bar for a hundred01:27:01
since in general everything is up to maybe before but everything01:27:04
anyway you forget everything01:27:06
no, that means my position is a little01:27:10
different I think these are the questions01:27:12
changing turnover generation career01:27:15
these are things they are another person's plans01:27:17
order first to population process01:27:20
Now the population is gradually starting up01:27:23
Vishnevsky Anton thought about it01:27:25
that the population will reach 10 11 million01:27:27
billions and will begin to decline over01:27:30
two hundred years to go down to 3 billion01:27:32
it will be a different world we will be different01:27:35
you even look like you don't live like that01:27:38
today, so who could have thought that01:27:41
there 30 years ago about what will happen01:27:43
some smartphones, laptops, there I am01:27:46
I remember how I bought there 30 years ago01:27:48
laptop with inactive matrix it was01:27:52
some kind of thing there for Russia is not there01:27:55
color display01:27:57
everything changes very quickly, I would like this01:27:59
I would just like to pay attention to the topic01:28:02
discussing mechanisms because questions01:28:05
overpopulation is a separate issue01:28:10
thank you very much I think it's time01:28:13
move on to questions from viewers01:28:16
there are a lot of them, I will try it myself01:28:19
interesting that very this is very good times01:28:20
this then is interesting yes yes yes we have01:28:25
special rolls could be invented01:28:27
there's a lot to say about these topics01:28:29
I always say what it means to be talkative01:28:32
this is one of my main manifestations01:28:34
aging before01:28:36
such a question if humanity succeeds01:28:39
significantly extend life or even01:28:40
to achieve immortality then will it cause01:28:42
decline in fertility rate01:28:45
undoubtedly among humanity itself01:28:48
adjustable if you know that a hundred years01:28:51
back again returning to that already01:28:54
happens in different countries already in the village01:28:56
there were a huge number of children and there was01:28:58
colossal mortality from the world family01:29:01
my grandmother had one with children from01:29:03
of which 6 died that's what I'm saying01:29:07
paranormal when I recently and01:29:09
Sanka Laichi threw off a book01:29:10
Novosilsky01:29:12
Sergei Sancho01:29:14
1916 about mortality in Moscow cattle01:29:18
there are Moscow mortality tables01:29:19
province means out of 80 thousand people01:29:23
forty-odd thousand people died from 001:29:27
up to 5 years a01:29:29
surface aged 85 years there then01:29:32
about four hundred five hundred people per01:29:33
both sexes with total mortality01:29:36
was not 60000 not 80 1060 but where01:29:39
the remaining 20 but the fact is that this is a given01:29:41
synod synod means and01:29:46
accordingly in this situation it is01:29:48
signet I shout who managed to be baptized01:29:51
what's the matter with infant mortality other than01:29:53
the fact that there are other religions icon01:29:56
fate is not01:29:57
and there are probably you and crosses and01:29:59
correspond to some other people01:30:01
religions, including a colossal01:30:03
infant mortality rate01:30:05
the ladies did not have time to christen this question, they01:30:08
without affecting, but the main contribution01:30:10
after all, we have this infant mortality rate01:30:12
huge proportion of child mortality in01:30:15
frying time is better here01:30:18
when they say that they used to be lower or01:30:20
this is up to the level of the Jedi01:30:22
continued life at birth because01:30:24
compare lived to be 30 years old, come on live01:30:26
It's still completely calm there for 20-30 years01:30:29
there are calculated indicators everywhere for me01:30:31
always if you look at the history of the 19th century01:30:35
Russia of the 18th century a huge number01:30:39
famous government officials01:30:41
figures who rocked 70 years before01:30:43
80 ancient world ancient Greeks ancient01:30:47
Romans01:30:48
60 70 80 thousand these are men especially01:30:51
man we know live less therefore among01:30:54
my one very serious point was missed01:30:56
Of course I understand that it’s impossible for a long time, well01:30:58
what is expected duration01:31:00
life when option among sale in01:31:01
Japan is 1984 there, what does that mean?01:31:05
they are burning, well, how did everyone who died in add up?01:31:07
this year and thought no, this01:31:09
age of death this is in english this01:31:13
correctly called life expect Nancy01:31:15
that is, this is the expected duration01:31:16
life is a virtual indicator and so01:31:19
these 84 years in Japan and 50 years somewhere in01:31:23
in a poor African country this is a few01:31:25
they are living now and this is virtual01:31:29
show which is calculated01:31:30
as follows for this year is taken01:31:31
mortality in different age groups and01:31:34
based on mortality in the rout01:31:36
constructing a virtual survival curve01:31:39
those born this year if it01:31:41
the mortality rate will remain the same as in01:31:43
this year the curve we talked about01:31:46
the seventh bottom and will look like this01:31:47
way that the average duration01:31:49
life will be 83 based on him the word is not from01:31:52
I have nothing to achieve01:31:54
the order of the Russians is very important yes yes yes01:31:57
so this is what we have for today01:31:59
day it's like this and then you talk about us01:32:00
expectedly continued actually it01:32:02
not connected in any way it didn't add up everything01:32:04
Sergei, fifteen years old, has no time for his head01:32:06
virus among for the summer I tracked how01:32:08
Since I wrote a book, it means it was somewhere01:32:10
for June-July our indicator is 73 years 6001:32:13
65 is the average for men and women01:32:17
it is now known that she is here for two years01:32:19
by the twentieth year it had already fallen by 201:32:22
years calculation cafe this will continue01:32:25
fall of the night we left the questions man01:32:27
which halls of man species such dare01:32:29
you are there for asking about one thing01:32:30
I answer, I have it on hand, so I have a question01:32:33
was like what kind of birth rate does it seem to me01:32:35
Of course, she can see it in different ways01:32:37
countries so I can continue my life growing01:32:39
then not all dreams are to01:32:41
the population needs to reproduce01:32:43
each family had 3.3 or so children in01:32:46
average01:32:47
2121 no this is this you are not taking into account01:32:51
infertile marriage you don't consider oh no01:32:53
I don't go for every woman but01:32:55
if the population as a whole is about 3.3 per01:32:58
family and then will not change01:33:01
the size of a woman's height should be01:33:03
even more like this is going on now01:33:04
depopulation yes we have numbers in01:33:07
many countries themselves are not decreasing due to01:33:10
it's another matter that she also01:33:13
fits why many die too01:33:15
if they don’t die then depopulation01:33:18
maybe it won't be so intense but01:33:20
there will be no new blood01:33:22
I think we need to understand what can happen01:33:25
what states can do01:33:27
that means doctors are state institutes01:33:30
yes, there are three separate people here01:33:32
categories people themselves medical community01:33:35
and what the authorities can do to01:33:38
smart people lived longer than needs Russians live01:33:40
very little but probably the main thing01:33:43
can the government create it?01:33:45
institute01:33:46
geo geo anthology is very important01:33:49
moments to study the mechanisms are needed01:33:51
tool and because today everything01:33:53
is in the hands of enthusiasts by the way I01:33:56
I forgot to say that the Russian school01:33:58
Soviet school of gerontology where01:33:59
belongs to Lesa Nikolaich I am a piece01:34:02
caught a small one01:34:03
the most powerful school of gerontology in the world01:34:06
it was very important it was very important01:34:08
because Russian scientists always01:34:12
the voice was very loud from01:34:14
Mechnikov's death prays a pilgrim01:34:16
Bogdanov is a completely separate person01:34:18
which is underestimated today in everything01:34:21
in the world and in Russia, including this01:34:23
colossal brain and01:34:26
Krichevsky who marched with the white troops01:34:29
from Crimea and created an international01:34:31
associations of gerontology faith 3 which01:34:33
the association that was created saw the sixth01:34:35
year in St. Petersburg under the Russian01:34:37
she left the Academy of Sciences this year01:34:40
to this will be an international organization01:34:42
what can doctors do today?01:34:46
because the medical workshop is very large01:34:48
Today doctors don’t study01:34:52
gerontology01:34:53
but the time has come for such things01:34:56
so that the basis of gerontology is included in the course01:34:59
higher medical education as well as01:35:01
geriatrics, which today is included01:35:03
in full-time education she used to be a post01:35:06
diploma in medical education today01:35:09
enters in training begins to enter here01:35:12
the project was also accepted as a solution01:35:14
government last year means that01:35:17
doctors forgot this phrase what do you want01:35:19
age so that they understand and can01:35:22
people are raised by doctors who01:35:23
understand both the basis of gerontology and01:35:26
geriatrics01:35:27
Well, for the citizens themselves, the most important thing is01:35:31
do not shorten life expectancy for01:35:33
Russians whose very characteristic is that01:35:35
us and your life process with specific01:35:38
reasons why Russia doesn't live long01:35:41
why such a colossal mortality rate01:35:43
men of middle age groups and01:35:44
I have a whole book on this topic01:35:46
there is that's why here's the main gear01:35:50
protector for Russians do not shorten here01:35:54
it can make three blocks that is in01:35:57
Each block can do a lot more01:35:58
add and say but overall here it is01:35:59
create an institute and start teaching01:36:02
doctors and accordingly do not reduce it01:36:04
very important thank you we have a question with01:36:08
donate01:36:10
mac mac asks and hypotheses cam01:36:13
zynga you think right about01:36:15
old age, what about his research?01:36:16
life extension based on stool analysis01:36:19
kasmir copov01:36:20
cool 1 kopeck these are separate stories of course01:36:23
this is a very interesting animal but01:36:26
bombs I mentioned was not a college rating01:36:28
this is what I think this is my persona01:36:31
garene what a naked mole rat is not01:36:34
truly an ageless animal01:36:36
will become obsolete very slowly, that's a waste of time01:36:40
Yes, the words here are most trivial01:36:42
there are suitable ones, we just don’t notice but01:36:45
if we catch it recently, that means who01:36:47
then the yaga said and asked how you were01:36:49
determine the age of the animals we01:36:51
caught how we learned it means01:36:53
what the human eye cannot detect01:36:55
the age of the digger but with the help of instruments01:36:58
you can determine the age01:37:01
age age means it changes and01:37:05
then why do they die before the night01:37:08
they must die, they die from fights01:37:10
how first of all this snake and 801:37:13
and they fight among themselves, we know that, yes01:37:16
I love the sound very much love rikudo01:37:18
accordingly his cheeks were like this01:37:21
some cobra snake settle in01:37:23
Matera we stood and I was the falcon of the feet01:37:26
there was a cobra lying there, we just didn’t notice01:37:27
settle cobra these diggers they01:37:30
will die quite quickly or from stress01:37:33
or she will eat them later as much as I01:37:35
I understand that diggers are very susceptible01:37:37
viral infection01:37:38
oh no, they are just very resistant to01:37:42
various diseases and this all the time01:37:43
it is emphasized in all articles that they01:37:46
just very stable bodies are one thing in01:37:49
that you understand above should01:37:51
study we spoke correctly yes on them01:37:54
soil should be a control population01:37:56
must have local animal experience01:37:59
no matter what age they are and01:38:03
their age is not well known01:38:05
high small end I'm not on my own01:38:07
that's how it's done in Berlin in Berlin01:38:11
the zoo has a large population of these01:38:13
naked mole rat01:38:14
Ivan Petrovich Skulachev is often shown01:38:17
films shot there how they run in these01:38:19
plastic pipes as you see how they are01:38:21
live how they fight and so on yeah01:38:23
ugly one with huge teeth01:38:25
here we are filled with cute ones, but I'll put them on01:38:30
but that's the point, that's what the question means01:38:32
was like how right this is and no trace of that01:38:35
first of all they live a very long time01:38:37
you'll be tired of shooting survival curves in01:38:40
Secondly, they are expensive, where can I get a table from them?01:38:41
they live for a long time in artificial conditions01:38:44
there are no conditions and he catches in nature, which means01:38:47
this is the woman who started it all01:38:49
it does which to caught forgot her01:38:51
last name means which she caught from01:38:53
Romana really went 30 from there01:38:55
30 year old naked mole rats01:38:58
how did she find them, how did he01:38:59
determined its beginning determined its age01:39:01
I think teeth means age01:39:04
still need to determine if they are rodents01:39:06
and I also give them wives there all the time01:39:08
something about Russia, probably, but I’m not an expert01:39:10
we can determine the age, it means animal01:39:12
grows old and he changes from the Entente where01:39:15
suppress or micro usb if I have01:39:18
ram threshold can further he is old in01:39:20
not just every year at the ring01:39:21
formed by the tree milks you don't know on01:39:23
We're just getting old in life, we'll change the conditions01:39:27
if we change the condition then with great01:39:29
it is likely that he will die01:39:31
let's make the digger run away from the snake then01:39:35
most likely animals01:39:37
which older ones up or screaming came01:39:39
through some threshold that is not01:39:41
We don’t visually identify voices, well01:39:43
more likely to raise not a year01:39:45
today is such a good day01:39:47
The naked mole rat does not have biomarkers, but01:39:50
you want something else, he understands01:39:52
but I know that some experiments01:39:54
published on the legs for black both of them01:39:57
were made literally by one or two stomachs01:39:59
of course they are right there, here is the queen01:40:01
riding queen give them all queens01:40:03
then little as we know, but in England01:40:05
just one yes, you know, that’s why01:40:09
that's when it's 1k and they say01:40:12
imagine how we did01:40:13
experiments when a colleague tells me01:40:15
there were 2 queens, is one necessary for01:40:18
experiments we had to video means01:40:20
use for experiment or only01:40:22
you have an experiment on one animal, well01:40:24
yes, but it's a very expensive scar01:40:27
maybe it happened by chance too01:40:29
try separate statistics but what kind01:40:31
no statistics yet, it’s different01:40:35
evolutionary design of your illnesses01:40:38
which they basically die in comfort01:40:40
Russians basically give them peace01:40:42
consequences of lyrical format sclerosis01:40:44
there percent die from addictions01:40:47
wandered into the second between oncology and 201:40:49
oncology places, for example, are known01:40:52
known fact01:40:54
disease and atherosclerosis01:40:56
he's already spending work on Marchand's disease01:40:58
ronechka volmar shandra chicago means01:41:01
clinical model model that means01:41:05
or rather the animal model was rabbits01:41:08
Rabbits are experiments. negligent01:41:11
the beginning of the last century before the beginning of the Permir01:41:15
wars but rabbits don't get sick01:41:18
atherosclerosis and force-fed01:41:21
they poured cholesterol down their throats, which means they01:41:24
still didn’t get sick in those clinical01:41:26
forms and such heaviness as a person01:41:28
when they stopped feeding the date01:41:31
respectively these this or sclerosis they have01:41:33
as if01:41:35
changed that's why here at01:41:38
studying the naked mole rat, yeah01:41:40
interesting but we are studying this case01:41:42
that we are studying the structure of the naked mole rat01:41:45
not the aging of a person is on the head of the earth01:41:48
which just appears to our eyes01:41:50
somehow we really don’t exist here01:41:53
this is a family of rodents it is very large01:41:55
the biggest thing but the idea was in general01:41:58
simple because he seems to be too01:42:00
relative text rattan stroller01:42:03
rat mole yes this is the same color01:42:05
there are many animals that live there01:42:07
quite a lot of people live there for a long time and01:42:10
six years old ipad siringar you wanted to marry01:42:12
find here there are 2 wheels and there are goals for the game01:42:14
which, in principle, is genetically01:42:17
similar, but one lives little and quickly01:42:19
gets old and the other one is comfortable and doesn’t last long01:42:21
getting old wanted to find something in Wright and01:42:23
thinking about if they find this one01:42:25
mechanism that allows naked01:42:27
a digger will live a long time, you might think01:42:29
how to use this mechanism01:42:31
day and new it is still among the ancient Greeks01:42:33
why are different animals similar?01:42:35
the sizes are even different, but because01:42:38
evolution has arranged everyone like this01:42:40
occupies its niches and why then people01:42:42
live cancer strategy p strategy that is01:42:47
in this case, for some reason in different environments01:42:49
living animals in the air under the ground and01:42:51
can live, for example, the same lives and01:42:53
respectively living in the same environment and01:42:56
there's even one living nearby, I think there's a rat too01:42:58
there is a touch and here is another beautiful side01:43:02
this means the rats have been there for three years01:43:05
And01:43:06
diggers for 30 years but so what to do01:43:09
what does this have to do with a person?01:43:12
interesting models need to be studied01:43:14
we need to create an institute we need to create01:43:16
institute svvarim definitely yes but01:43:18
I need a tool, I need it and cetus01:43:21
our next question is also about mice01:43:24
question about a recent article on the site01:43:27
programming mouse cardiomyocytes01:43:29
which allowed to restore the heart01:43:30
your muscle I didn't have a run01:43:33
this method in the treatment of aging01:43:35
here I am just a few days ago01:43:39
it was Thursday if my memory serves me right01:43:41
I was at a conference called01:43:43
molecular biology rational01:43:45
predictive night was chic01:43:48
marriott grand hotel conference01:43:50
I'll be there one day and she arranged for01:43:52
hello meta kejan company here's atom would01:43:55
all our famous experts spoke01:43:58
means just pair programming in01:44:01
including genome editing01:44:03
I'm not good at this, I can do it right away01:44:07
say here but in these specific01:44:08
molecular details, although there are a lot for me01:44:10
there was some interesting stuff there but I tried really hard01:44:13
understand, but I made one conclusion for myself01:44:16
that's what you said animals and people before01:44:19
different like that01:44:21
genome editing01:44:23
programming on animals is possible01:44:26
achieve and what I learned from these lectures01:44:29
basic as an amateur01:44:30
you can practice in this and achieve01:44:34
some success and publish this01:44:36
article in the evening but probability01:44:40
wrong high enough mistakes01:44:43
that is, you reprogrammed it01:44:46
or yes but if you want to fix it too01:44:49
person then you will have to when01:44:51
ready for the fact that out of 100 attempts 9901:44:54
will fail if you are willing to take risks01:44:58
99.99 mice I might be ready01:45:01
take a risk and 99 people don’t, so on01:45:06
today I emphasize this01:45:08
everyone is serious01:45:11
approaches tomsk risport for example this one01:45:14
genome editing, but apparently not yet01:45:17
don't work so effectively for us01:45:20
could use them for people though01:45:23
of course it's very interesting and01:45:25
promising, you bet it's not01:45:28
tomorrow is when it will give01:45:31
some practically my result01:45:32
opinion yes from the point of view of aging01:45:36
as we grow older guitar security01:45:38
soon the hetero top is getting old01:45:40
different systems of all01:45:42
individually imposed that we01:45:43
different and01:45:44
phenotypic epigenetic in us01:45:47
different somatotype and that is different01:45:49
metabolic design means that01:45:52
number and in different ways as the ring said01:45:55
where how many and what is aging?01:45:58
stochastic execution of genetic01:46:00
programs that is 1 aging heart01:46:02
the other's heart system is faster01:46:06
skeletal muscles 3 nervous system01:46:09
so I'm not either, I'm not familiar with this01:46:12
article but that means I can say that you are us01:46:14
we can make a heart but for example dimens01:46:17
if it occurs in a person it is more01:46:20
the world will not matter to this person01:46:22
good cardiomyocytes01:46:24
this means that the creative functions will be zeros01:46:27
a big problem even for me now01:46:28
come on, the game is called Alzheimer's01:46:31
there is just a question about whether it is possible01:46:33
the length of stories mentally about01:46:38
this is such a broad topic01:46:41
exists today01:46:45
three approaches01:46:47
turn it around I would say this means the beginning01:46:49
Of course you have to do it in April when you’re young01:46:52
age01:46:53
do a genetic analysis on01:46:54
genetic polymorphism look who01:46:56
there are some diseases especially those who01:46:58
have relatives with Alzheimer's disease01:46:59
if you have one direct relative01:47:01
Laziness is literally Alzheimer's disease01:47:04
grows in four the question waited01:47:06
you can't make anyone obsolete mintaka01:47:08
make there a joker worth it per person01:47:10
Grian means I'm a pragmatist, so I proceed01:47:13
from the fact that people want to understand what these01:47:15
what can be done is done genetically01:47:18
analysis and polymorphism understand if the risks01:47:20
to modify01:47:21
in cognitive it’s more like 30 percent01:47:24
factors but this is an estimated opinion in numbers01:47:26
very difficult of course01:47:28
I don’t even know the numbers, this opinion is not mine01:47:31
of the entire clinical workshop 30 percent01:47:34
can be modified somewhere01:47:38
the next block is divided into three parts01:47:41
it's a change in nutrition it's physical01:47:45
activity and cognitive training01:47:48
carnitine and this is money for me, I know that01:47:50
people with more education live longer01:47:52
professors live even longer than academics and01:47:55
so on and so on because01:47:58
part of the acceleration is Quentin and01:48:00
aging convective aging but01:48:01
worsen for example the presence if01:48:05
cognitive change collective01:48:07
the disorder will progress to the stages of dementia too01:48:09
all diseases accelerate01:48:11
accelerates all diseases including01:48:13
course of the penny variety and underlying pathology01:48:15
this leads that is the position01:48:19
tumblr viable translated01:48:22
the situation accelerates quite quickly01:48:24
unviable of course cognitive01:48:26
the training he pays attention to is very important01:48:29
but preferably you always say01:48:32
how will you do it then study there01:48:34
from crosswords to study to language learning or01:48:38
write a book about what you lived about, I don’t think about it01:48:40
just slow down this aging but remove it01:48:43
him in the mental store in my opinion01:48:45
You can't take it completely. with swords yes I01:48:48
also material every 10 years 3 percent01:48:50
neurons, that is, each of the 20-year-old01:48:52
age there 03 rights inside percent01:48:55
every year accordingly 3 percent01:48:57
every every 10 years we are lost and on01:49:00
at some stage Alice Nikolai said that01:49:02
we will cut with the same Nero with whom01:49:05
we were born we have sex cells in01:49:08
two areas I think that the blaster is neither01:49:10
another matsat elite cells themselves01:49:12
neurons never give in01:49:14
comparing wounds will never share the essence01:49:16
elite cells are sometimes very rare but01:49:18
and at an early age it is very01:49:21
there are few of them practically so01:49:23
compensate for the loss of nero duck and himself01:49:25
the main problem is we made you new01:49:28
the neuron was built there, the connection is01:49:30
the chain is broken, yes the thing is that01:49:33
synapse brain architecture is very01:49:35
more difficult, maybe even more difficult than ours01:49:38
dna imagine there 100 tammy 10001:49:41
billion neurons there are 8 6 billion01:49:43
different estimates and each neuron has different01:49:46
1000 to 10 and up to hundreds of thousands of connections01:49:49
Rate how difficult this is01:49:50
design of colossal complexity01:49:52
of course when this is a hologram01:49:55
breaks down with age and that's just you01:49:57
slowdown but from the collapse of holograms01:49:59
than she could be there some 7d in01:50:03
some 7d be up there or there01:50:05
10d this is very difficult here are the losses01:50:08
it is precisely these connections that she01:50:11
hold up teach hard thank you very much01:50:14
in fact, time is coming to an end and there is01:50:18
a few questions about the bibliography01:50:20
books that you listed but I think01:50:23
what we'll just do is add it in the description01:50:27
list so that no one loses books but me01:50:30
Still, I’ll ask in addition to the techniques that you01:50:32
mentioned that you can still read on the topic01:50:36
aging to ours, I recommend the book01:50:40
proliferation of steel I don’t remember what it’s called01:50:42
the screen is old, my book is not a visa and01:50:45
then no and then no it’s just there01:50:46
really some good books01:50:48
I even have a slide that01:50:50
I show it here in my lectures, well01:50:52
So I gave lectures on aging in Harbin01:50:55
Polytechnic feel with me01:50:57
there is a slide there in English01:50:58
to which all these books are listed to01:51:01
unfortunately not everything is in English01:51:03
part to read when you're ready, but in01:51:06
basically it's not a problem I can do it01:51:08
then forward it so they can post it01:51:10
just answer yes attached to this01:51:13
that means I write about 3-4 books a year then01:51:17
I have a pretty big one01:51:18
performance01:51:19
I can recommend this book too01:51:21
what book but this is not but aging is01:51:24
it is about longevity that this topic is related but01:51:27
we won’t sow the same thing, this is this01:51:30
exactly what is longevity? centenarians01:51:33
phenomena Abkhazian Okinawan blue01:51:36
What are Madame Calment's reasons here?01:51:39
pitfalls mean the ends of books I01:51:41
I usually give a bibliography list01:51:44
literature that means for whom it will be hard01:51:46
although I write the book in good Russian01:51:49
here's a book within a book, it's a secret01:51:54
centenarian Jeanne Kalman is01:51:57
super centenarian who lived for a long time01:51:59
documents one hundred twenty two and a half01:52:01
she began living in 1875 during01:52:06
Alexandra, in my third opinion, this means01:52:09
died in ninety-seven, well, 190001:52:11
with almost two years before the moisture transition01:52:14
do you get along with Putin?01:52:15
surprising but that means here01:52:17
fiction book to fiction01:52:18
book for women nested scientific book01:52:21
that is, this is not a mixture of this matryoshka book01:52:23
just like I think there were two01:52:26
human that means mother and daughter strength01:52:30
some reasons01:52:31
switched places she died mother and01:52:35
my daughter began to live according to her document01:52:37
this is the book I’m giving it to you big01:52:40
goal class then thank you thank you01:52:45
I'll remind you what we have in the studio today01:52:47
were Alexander Nikolaevich Khokhlov doctor01:52:50
biological sciences department head01:52:51
evolutionary flowers of gerontology01:52:53
biological biology faculty01:52:55
Moscow State University and Valery Mikhailovich Novoselov01:52:57
director she is a scientific medical01:52:58
Gerontological Center and Chairman01:53:01
sections for ontology are mine thank you01:53:03
thank you very much for sleeping very interesting01:53:06
called for a conversation about thank you for your patience01:53:09
no one has gained any more patience01:53:12
great pleasure I hope ours01:53:14
the audience is also a language or some kind of you01:53:17
tips for fighting aging books we01:53:20
let's actually add it because01:53:22
there were a lot of authors01:53:25
so look in the description and see you on 3001:53:30
September we will talk about01:53:32
emotional burnout01:53:33
thank you very much, goodbye and goodbye01:53:36
thank you for meeting youDescription:
Почему мы стареем? И как удаётся не стареть пресноводной гидре? Как можно увеличить продолжительность жизни? И получится ли сохранить личность у бессмертных особей — обсудим в Рубке ПостНауки. 00:00 Начало видео 00:13 Начало трансляции, введение 01:28 Что такое старение? 08:50 Геронтология — наука о старении 12:22 Аналогия со старением автомобилей 13:46 Кратко о перспективах исследований старения человека 15:25 Механизмы старения и маркеры старения 21:06 Запрограмированное старение 29:00 Биологический возраст человека 37:50 Улучшение качества жизни важнее увеличения продолжительности жизни 47:25 Животные, которые не стареют 53:21 Половые клетки — бессмертная бесконечная клеточная линия. Старение клеток 59:29 Геропротекторы 1:07:16 Долгожители и супердолгожители. Длительные наблюдательные исследования. Биомаркёры и возраст-зависимые заболевания 1:15:37 COVID-19, геронтология и старение 1:17:40 Старение популяций людей 1:20:07 Геропротекция человека. Что можно сделать для продления жизни? 1:22:51 Можем ли мы стать бессмертными? 1:28:37 Вопросы зрителей 1:50:30 Что можно почитать по теме? Участники беседы: Александр Хохлов — доктор биологических наук, заведующий сектором эволюционной цитогеронтологии биологического факультета Московского государственного университета имени М.В. Ломоносова Валерий Новосёлов — Директор АНО «Научно-медицинский геронтологический центр» Председатель секции геронтологии МОИП при МГУ Алина Адырхаева (https://postnauka.org/themes/adirhaeva_a) — продюсер ПостНауки Поддержи ПостНауку — https://postnauka.org/donate/
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