Download "How To Activate SIRT6 | Professor Vera Gorbunova Ep2"

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0:00

SIRT6 Activation without gene therapy

1:10

SIRT6 activities

3:00

fucoidan

5:40

fucoidan preclinical trial

8:36

SIRT6 & fatty acids

10:40

with Yamanaka factors

ГЕНЕРАЛЬНАЯ ЧИСТКА ВСЕГО ОРГАНИЗМА — НЕВЕРОЯТНЫЙ ЭФФЕКТ!

ГЕНЕРАЛЬНАЯ ЧИСТКА ВСЕГО ОРГАНИЗМА — НЕВЕРОЯТНЫЙ ЭФФЕКТ!

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[Music]

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so okay apart from uh genetic methods of

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looking at this Gene gene therapy uh how

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else what kind of can we do

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now yes so we can also use chemical

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activators because there is one way just

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let's put more protein in mhm another

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strategy well let's use the protein that

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we already have that our cells are

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already making and make it more active

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because C six is an enzyme so we can

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activate it enzymatically we can

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potentially also try to trick cells into

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making more of it uh but that's kind of

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a different approach or we could

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increase the activity of the

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enzyme uh we are also exploring it uh

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and there are several companies that

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were looking for chemical activators of

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C six so here we had some Edge because C

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six is an enzyme and it has two separate

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enzymatic

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activities one is called detil so it

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removes acle group from other proteins

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and another one is ribosylation it adds

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a ribos group so there are two

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activities uh both are important for

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various cellular

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functions um but what we showed it was I

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don't remember if we discussed this

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Study last time or not that in human

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centenarians we found a variant of C six

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uh that has ration activity enhanced but

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not

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just and from this we concluded that

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this is the activity we really want to

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go after because acation is important no

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question about it and I I believe it's

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particularly important early on uh

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during development when you know genome

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has to properly function to make a baby

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correctly but during

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our uh you know subsequent life adult

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life um perhaps rosil is what becomes

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more critical for

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longevity uh but all of the initial

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screens for C six activated were focused

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on the

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culation and we started looking for

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activators of rosil so we are doing it

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right now we're screening

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mhm uh but from the activators that were

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discovered

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previously uh we just tested them

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because they all were discovered as

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distilation activators and we thought

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okay let's check maybe some of them do

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both maybe some of them activate both uh

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and one of them did both because most of

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them really did nothing to to ration

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they were only targeting one activity

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that's but one was activating both and

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that's a interesting molecule um called

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fuken uh that is derived from brown

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seaweed uh which is very safe people eat

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brown seaweed it's sort of a staple of

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Asian Cuisine in Japan in South Korea

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people consume a lot of brown seaweed

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and soups and

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other other

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appetizers um and so we got kind of

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excited because these are countries with

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highest life

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expectances and they eat a lot of this

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um so we really started investigating

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further the effects of fidance from

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seed

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so right so I understand that you that

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not all the fiden works right it's quite

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a complex molecule that can be like

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different um that's correct so Fon is

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kind of a family of

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molecules and their backbones are

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similar but they are not the same in

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every algae species there are

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differences in in the structure how

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those sugar Moes are organized relative

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to each other and we've been testing

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various

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isolates of Fons and not every not each

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one activates 2 six we found maybe every

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third does others they have no effect we

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even had some that inhibited C oh so do

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you know what the kind of mechan

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mechanism of action is like why it's

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different

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well probably because they have

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different structures right and we are

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trying to figure out why um we don't

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know we don't know this minimal

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structural unit of fiden that's

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important and we are working with sugar

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chemists right now to identify the

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structural unit and I hope that once we

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succeed then we can make a better drug

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out of this but right now uh we can just

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see right okay um so I believe you tried

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to Co in in mice as a as a c six

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activator right because as I said like

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the previous one was was genetic so yes

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can can you talk a little bit about what

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you saw with Fon in

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mice yeah that's that's actually very

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exciting that you know the results

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exceeded our expectations we uh started

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giving

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to aged mice uh sort of

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middleaged not very old but about one

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and a half year of age and we just kept

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them on this supplement and we had

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control group of mice that didn't

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receive

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fuken uh and then we were measuring the

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Frailty scores every month uh we

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measured the inflammatory cyto kindes in

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the blood um and the physical activity

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like you know the walking speed and grip

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strength and various parameters and

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there was clear benefit uh for the mice

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uh taking FID and it was very clear it

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continued um and then I think an update

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to our previous conversation my fiden

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group actually survived longer so it

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even had effect on

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lifespan the what kind of dose were you

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giving them was it something that a

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person would be able to

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mimic yes it wasn't too high well we

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basically we started

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from um sort of crude preparation of FID

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and it wasn't Ultra Pure because um we

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wanted it to be kind of similar to what

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humans would take because you can make

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Ultra Pure fuken but then the it would

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be cost prohibitive so we took partially

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purified kind of crude uh preparation

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not not just ground up seaweed but you

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know first purification steps and we

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were giving it to mice U mixed with

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their Chow diet so it wasn't a huge dose

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I think for a human you know translating

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the dose between Mouse and human is not

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linear and it's kind of difficult to say

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because we are much larger and we have

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different surface to volume ratio um but

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I would say approximately four grams of

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fuken would be similar for for a person

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so for do not age right do you do you

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test

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Eiden is is yes yes so we test uh we

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test their samples to make sure that

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they activate uh C six and then then

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they call it C six activate

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right so I saw in one of your papers

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that you talked about the activation of

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cerx requiring fatty acids or at least

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being enhanced in the presence of fatty

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acids I believe so first of all GNA is

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that correct and would there be any

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advantage would that talk talk about

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when you should take um aert sex

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activator to try and have like fatty

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acids around at the same time

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yeah you know it's an interesting

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question we haven't tested it in mice

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because yeah potentially we could try to

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further um give them different diets

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with the fatty acids um so fatty acids

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they were shown to activate the

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aculation activity uh we didn't um I

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think we tested it with ration we didn't

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see much of an effect although I don't

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know how that would play out in

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combination with fuken that's again

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something to try uh so could be Tred

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potentially you know it's really

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interesting but um it seems that

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various sort of treatments or diets um

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that from um people believe to be

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healthy and that there is evidence like

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color restriction even not similar

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uh intermittent

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fasting many of them activate C two in

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six of course the effects may be quite

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mild um but we see very interesting

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relationship that often well if we know

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that these types of fatty acids are good

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and like other studies showed they're

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good and then oh we find they activate

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cin six so it's C six really seems to be

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this kind of Hub uh controlling many

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processes related to aging and this is

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why just healthy lifestyle is

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good but obviously we want to have

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stronger effects and this is what we get

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with with fid and s36

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activator so one of the things C6 does I

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believe is that it well it's part of the

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the fixing the transposons is helping

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package the chromatin so so basically

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helping with the epigenetics so I saw

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you also talked it said it would be

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interesting to kind of combine C six

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with reprogramming with like yamanaka

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Factor

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reprogramming um could you talk a little

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bit about that and well a is that

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correct and B could you talk a little

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bit about how that would work or or is

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SE six working totally differently from

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the the amakas in terms of the way that

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it handles you know it is a difficult

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question you're asking and we've been

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thinking a lot about this

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uh because

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um C six is doing something similar in a

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way that it rejuvenates the epig genome

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so our epig genome gets disorganized as

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we age and this may be the driver of

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Aging Al together uh but how do we

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rejuvenate it because what yamanaka

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factors are doing they just take

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everything and kind of completely redo

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redo it and just bring us back to this

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um embryonic form um and that is

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dangerous intrinsically because when

00:12:08

cells lose their identity they can then

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turn into cancerous cells and this is

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why people working on reprogramming they

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uh working to develop strategies where

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you do it just a little bit you you

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don't go all the way you don't turn our

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cells into embrionic cells which would

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be lethal but we just do it just one

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step two steps but not all the way um

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what C six is doing here is you know

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similar in a way that it rejuvenates but

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it really doesn't change the fate of the

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cell it doesn't even it doesn't even try

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to do it so there is no danger of losing

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cell identity um because with respect to

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transposons C six just goes in and

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recognizes transposons we don't

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completely understand how and condenses

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them into heterochromatin it doesn't try

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to rewire the whole

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system um so in this way yanaka factors

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um work you know in a very dramatic way

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they just change everything um C six

00:13:21

just comes in and there are some places

00:13:23

that losen up and it

00:13:27

tightens right so it's working in a

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totally different way um and okay so

00:13:33

like combining them may not so combining

00:13:36

them yes so to to the question of

00:13:38

combining them um initially we thought

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that well perhaps we could try to

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combine them we've done some preliminary

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experiments in that way and in in some

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way C6 may actually prevent yamanaka

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factors from doing what they want to do

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because C6 doesn't want to allow the

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genome to completely

00:14:00

rewire um so in a way they could be

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antagonistic to each other it can if if

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let's say we wanted to um complete

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reprogramming to take a cell and turn it

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into embryonic stem cell so C six would

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actually be an impediment to this

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process because it wouldn't let the

00:14:21

whole epigeneium to open up and then

00:14:24

assume new structure um if we only want

00:14:27

to do it in partially so there may be

00:14:30

benefit in combining them so maybe C6

00:14:33

would not let the cell reprogram

00:14:35

completely which is not what we want in

00:14:38

the case of um somatic Rejuvenation but

00:14:42

maybe it will kind of limit uh so this

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is something we actually want to study

00:14:50

in the future so that's one our

00:14:53

[Music]

00:14:57

list

00:15:01

[Music]

Description:

Here Professor Gorbunova talks about the two functions of SIRT6, deacteylation and ribosylation, the importance of them and how they can be activated. She also touches on chromatin remodeling and Yamanaka factors. Some links are affiliate links so we will earn a commission when they are used to purchase products. *DoNotAge* 10% discount code MHS https://donotage.org/products SIRT6 Activator https://donotage.org/sirt6-activator , GlyNAC https://donotage.org/glycine-nac *Renue By Science* 10% : _https://tinyurl.com/4yrf4tv3_ Use SUBMHS for 15% discount on subscription orders Liposomal CoQ10 https://renuebyscience.com/product/coq10-powdered-liposomal-capsules/?rfsn=5832249.3a406d&coupon-code=345822 *ProHealth* 15% discount Code MODERN : _https://prohealth.pxf.io/c/3176409/1541296/17976_ NMN 1g capsules https://prohealth.pxf.io/Jz4dL2, CaAKG https://www.prohealth.com/products/prohealth-calcium-akg-longevity-500-mg-60-capsules-ph591?irclickid=wAJ1-ex5axyKTBqRyaxAhTFsUkHV5KxArVoIXI0&irgwc=1&clickid=wAJ1-ex5axyKTBqRyaxAhTFsUkHV5KxArVoIXI0 *NOVOS* Core & NOVOS Boost $5 off with code MODERNnow5 _https://novoslabs.com/?ref=3957_ *Insidetracker* 20% discount Code MODERN20 _https://insidetracker.sjv.io/NkbP7V_ ☕If you would like to support our channel, we’d love a coffee…thank you! _https://buymeacoffee.com/mhealthspan_ *Bulletproof* 15% off with coupon code: HEALTHSPAN15: _https://tinyurl.com/4npjk5vp_ *SiPhox Health* 20 % Code MODERN blood test (only in US & Canada) _https://siphoxhealth.com/discount/modern_ *Delavie Sciences* 10% Code Modern Age Defying Serum https://www.shareasale.com/notactive.html?3361641 Eye Refresh https://www.shareasale.com/notactive.html?3361641 *OmegaQuant* 5% discount Code MODERN _https://omegaquant.com/shop/_ ⏲️Chapters 00:00 SIRT6 Activation without gene therapy 01:10 SIRT6 activities 03:00 fucoidan 05:40 fucoidan preclinical trial 08:36 SIRT6 & fatty acids 10:40 with Yamanaka factors Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat 🌐Links in this video Dr Gorbunova's website https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/ Sirtuin 6: linking longevity with genome and epigenome stability https://pubmed.ncbi.nlm.nih.gov/34281779/ *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ************************************************** 📖Books *Dr Peter Attia* Outlive: The Science and Art of Longevity - _https://www.amazon.com/ *Dr David Sinclair* Lifespan Book – _https://www.amazon.com/ *Dr Sandra Kaufmann* The Kaufmann Protocol: Aging Solutions _https://www.amazon.com/ The Kaufmann Protocol: Why we Age and How to Stop it _https://www.amazon.com/ *Dr Steven Gundry* - Unlocking the Keto Code - _https://www.amazon.com/ The Longevity Paradox - _https://www.amazon.com/ The Plant Paradox - _https://www.amazon.com/ *Dr Mary Newport* Clearly Keto: For Healthy Brain Aging and Alzheimer’s Prevention _https://www.amazon.com/ The Complete Book of Ketones: A Practical Guide to Ketogenic Diets and Ketone Supplements _https://www.amazon.com/

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