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Download "AGE REVERSAL -29.5 Years!! 7 Potential Benefits Of GDF11"

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DAVID SINCLAIR
david sinclair
Dr David Sinclair
DR DAVID SINCLAIR
biological age
reverse aging
joe rogan
lifespan book
Resveratrol
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NAD boosters
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extend lifespan
aging
rhonda patrick
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Fasting
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quercetin
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AKG
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renue
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GDF11
peptide
gdf11
peptides
reverseaging
nitricoxide
sirt1
berberine
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00:00:00
[Music]
00:00:06
anyway uh as I said it's ous natural
00:00:08
peptide it declines with age the
00:00:11
production ceases at age 74 that was
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pretty shocking I just learned that
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about a year ago and it has been posited
00:00:18
mostly by me and by Amy Wagers that it's
00:00:21
Natural Selections uh method to uh
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control our lifespan basically uh gdf11
00:00:28
repairs asess and stem cells
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and uh if if you run out of it your stem
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cell populations die and I don't care
00:00:36
what camp you're in telomers rap them
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iice and whatever you cannot survive
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without stem cells so you run out of
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gdf11 it's uh you can survive for a
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while but the stem cell populations the
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mesyl hematopoetic stem cells die off
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and it's game over uh gdf is a large
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molecule it weighs 45,000 Daltons it's
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31 times the size of thyroid seven times
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larger than insulin and 1.8 times the
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size of growth hormone so it has to be
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uh it has to be injected also something
00:01:09
else really fascinating about gdf11 at
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least I think this is fascinating its
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structure is conserved across all
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vertebrates uh cat gdf11 human gdf11
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orangutang gdf11 dog gdf11 all exactly
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the same that it shows how important it
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is to life like the structure cannot be
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screwed around with so I think that's a
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a really cool aspect of it here we go
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Dow this is what everyone's been waiting
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for these are my biomarkers you say okay
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this guy's been on on gdf 118 years what
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happened to him well my anti-as doctor
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Joe rapael he said you only prove thing
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you proved is you didn't
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die so thanks for the encouragement
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anyway the uh this Raphael is a
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biomarker genius he has the biomarkers
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of Aging it's 100 page report of every
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system you know cardiac neural immune
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come to New York and have it done cost a
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bit it cost a bit of money about 2,000
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bucks but it's it's it's incredible and
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he's been working on it 15 years so I I
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try to get all gf11 to take it and um
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you can see I got a lot of greed going
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on that's good those are all systems
00:02:22
where I'm much younger the stuff I'm
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really proud of I actually got pretty
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emotional when I when I got this I this
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sort of R if I sort of May me get this
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done I take care of everyone else's
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biomarkers so I'm pretty bad on my own
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but uh anyway I showed a I showed a a
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cardio age of 35 I'm I'm 64 and A2 by
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the way this is a place where I like to
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say I'm actually older than I am but I
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really am 64 and A2 and
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uh so thank you neuro age of 42 and a
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pulmonary age of 41 and on the bottom I
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can't really uh this is where these
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little monitors don't work so well okay
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at the bottom the how do you how do you
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get to this how what biomarkers feed
00:03:02
into these this this is called comparing
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systems of the biomarkers of Aging
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report what biomarkers drive this okay
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the way to get your I know all the I
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know some of most of the algorithms how
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it works the way to get your cardio age
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down is to have low augmentation
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pressure so in 2014 this is eight years
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ago okay this is not this is not
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yesterday this is a long time ago Obama
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was President okay this was a long time
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ago eight years ago I was five it went
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down to four you say big deal that's 20%
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reduction just keep in mind that anyone
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else if I had a twin brother which I
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wish I did that would be great for my
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research I wouldn't I wouldn't give him
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any gdf 11 just say you know go just
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just go eat cheeseburgers and let's see
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what happens here so
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uh anyway I went down 20% and that's
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enough that's a Hu I mean they do factor
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in blood pressure and pulse my resting
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pulse is 55 blood pressure is you know
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normal 1280 but my AR elasticity is
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really low so I get a cardio age of 35
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it's pretty good now here this is the
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one I'm really proud of uh reaction time
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these are raw scores the CNS vital
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science test they actually you know they
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grade the curve and and when you're U uh
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older they they cut you slack and all
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this is these are raw scores not
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adjusted for age and I went from 914 to
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847 that's down 8% in 8 years you know
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what it would be for my twin
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brother be up and at least a percent a
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year uh probably you know percent and a
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half a year so I got a Delta here of
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about 20% that's that's believe me take
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my word for it this is a an incredible
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cognitive bio Market you want to keep it
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low at all costs absolute naives up 133%
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that gave me a immuno age that's not
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great 57 but I'll take it as I said most
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of these things head north no matter
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what you do c reactive C reactive
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protein this is Bill Fallon's favorite
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biomarker and you could say 2014 this
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preg gdf1 I was pretty bad man must be
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all the onion rings and God knows what
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else but now I'm 6 and that figures into
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um um uh oh am I done oh
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sh
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sorry oh I just want to show um this one
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uh this is uh Alfred he's uh 94 years
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old for Kent England and uh just want to
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show that he uh he's he's my hero he's
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30 years older than me he's done he's
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done uh incredibly well on gd% that's
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huge verbal memory visual memory up 65%
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neurocognition up 16% that's the whole
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Kahuna merg together mostly reaction
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type visual Acuity improved and uh this
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is his sleep for the last four months
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it's really important here yeah he's
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sleeping an hour get an hour more deep
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sleep at night
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that means more uh cell proliferation
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repair activity that's what happens
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during deep slip you want to maximize
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that a how do
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gf1 um in the last eight years I've run
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a gdf1 study and successfully dosed
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hundreds of people and and dogs and cats
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so I I know how to dose it uh pretty
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well uh gdf1 dose is carefully uh
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titrated adjusted to key biomarkers such
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as heart rate variability pulse R Us per
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minute uh like insulin or thyroid I do
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think gdf1 will eventually be classified
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as a hormone and like insulin or thyroid
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there's only a very narrow window in
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which it works okay you take too little
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doesn't do anything you take too much
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you get side effects just like the side
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effects not as bad as the side effects
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of a oh look the slides are right there
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hey at a at a clock
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uhoh P pays to look straight ahead okay
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well I can actually read that too so
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okay insulados is TI
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U insulados is titrated to blood glucose
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levels thyroid dose is titrated the T4
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thyroxin and TSH thyroid stimulated
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hormone you would not dose insulin or
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thyroid hormone without expert
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supervision and biomac feedback gdf11
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dosing is similar uh you cannot achieve
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optimal dosing without proper biomarket
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feedback please treat it with respect if
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I said oh you're going to dinner here's
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here's a vial insulin you know take a
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little before dinner maybe a little
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after d you say well that's nuts well
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gdf11 is is just as powerful so uh it
00:07:37
needs to be treated with respect and uh
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you you can run into trouble with it
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there are side effects like
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arhythmia okay the seven observable
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mechanisms of action of gdf1 uh uh the
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first the high level one is stem cell
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DNA repair uh but it over the last eight
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years we've seen and there's all paper
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is backing all this up by the way uh
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we've seen it it does a extensive
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cardiac repair and ath repair increased
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blood flow to the brain you're going to
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like that one that's all about memory
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and uh Reaction Time immune enhancement
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it'll up your neck nks and naive te's
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Hox Gene activation it shrinks to BPH
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cardiio hypertrophy senolytic it has to
00:08:18
be a senolytic it's all about set cell
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proliferation tumor surveillance
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eradication that's the one I've really
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done a lot of work on in the last three
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years uh it's a very powerful
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anti-cancer mechanism I've cured a lot
00:08:32
of cats and dogs of cancer and I'm sure
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humans are just around the
00:08:36
corner okay just a little bit of a
00:08:40
editorializing uh let's all be biomarker
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activists uh I think one of the problems
00:08:44
with this industry is that people don't
00:08:46
take uh don't report biomarker evidence
00:08:49
of the effectiveness of senolytics rapy
00:08:52
whatever there's a lot of biomarkers and
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some of them are very very expensive but
00:08:57
taking the big four blood pressure uh
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pulse HRV and reaction time it doesn't
00:09:03
cost you anything really well you put an
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empit under your bed it does HRV and
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pulse and uh it's it's very inexpensive
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you can't if you can't significantly
00:09:13
impact the big four then it's time for
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new regimen and I'll tell you something
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else if you can keep these the same for
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10 years which I have done you're you're
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uh you're greatly slowing
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aging okay let's go through the seven
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mechanisms of action uh number one is a
00:09:29
cardiac repair uh for the uh cohort
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which is over 100 people average heart
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rate V variability uh up 21% almost 22%
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due to cardiac remodeling uh I don't
00:09:41
know if a lot of you know HRV but it's a
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great biomarker it's easy to take I mean
00:09:46
everything takes it now the oil ring the
00:09:48
Apple watch so uh it's a great measure
00:09:51
of cardiac Fitness it overall health uh
00:09:54
average blood pressure down 5.7% as you
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age you know BP goes up uh average pulse
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down
00:10:01
6.3% average augmentation pressure this
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is a little bit more difficult to
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measure I actually have one of these
00:10:06
machines I have a whole biomarker Lab at
00:10:08
home that's how seriously I take this
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stuff but I have one of these machines
00:10:11
and this measures arterial elasticity
00:10:14
and uh that that Benes the hardening of
00:10:16
the arteries and it's down uh
00:10:19
60.7% okay this is a all the all gdf
00:10:22
lers get an M that goes under their bed
00:10:24
it's a very sophisticated research
00:10:26
device measures pulse and sleep and HRV
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and a bunch of other things and you can
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see with this guy here before gf1 you
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can see the uh pulse range is very high
00:10:40
and and which is not good you want you
00:10:41
want a narrow pulse range when you're
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you're sleeping and then he starts on
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the gdf1 and the pulse range shrinks
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that white line is resting pulse that's
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another great biomarker you can see it
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was very high starts on the gdf1 it
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comes down to 40 so it's looking really
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good but the reason I'm showing this is
00:11:00
this guy he actually uh he moved and he
00:11:03
didn't take his gdf1 for a month so all
00:11:06
of a sudden you can see the uh resting
00:11:08
heart rate come up you can see over
00:11:10
there the range uh gets much larger
00:11:13
fortunately after about a month he
00:11:14
restarts on the gdf11 and everything
00:11:16
returns to normal so you can see how
00:11:18
powerful it is things happen very
00:11:20
quickly you have to stay on it the rest
00:11:21
of your life but big deal you once
00:11:24
you're in the maintenance dose you can
00:11:25
do it that you know a couple times a
00:11:27
month and to thei you repair uh if you
00:11:31
got plaque we're uh we're the guys to
00:11:33
come to uh we reverse many cases of
00:11:37
plaque this is a CMT scan you can see on
00:11:40
the left the uh the guy's got plenty of
00:11:42
plaque and then on the right it's uh all
00:11:45
cleared and you could do a little bit of
00:11:47
plaque clear with diet but nothing on
00:11:50
this
00:11:51
level okay this is one of my favorites
00:11:54
increased blood flow to the brain
00:11:56
average gdf1 reaction time goes down
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122% there is nothing here at Brad fist
00:12:03
or on this planet that can lower
00:12:04
reaction time and I'll stand by that
00:12:06
statement anybody wants to take me a
00:12:07
task on that that's cool because I know
00:12:09
what I'm talking about here reaction
00:12:11
time is a very sad biomarker of Aging it
00:12:13
just gets worse and worse and worse as
00:12:15
you age that's that's a very depressing
00:12:17
graph of reaction time after 50 it gets
00:12:19
really bad so you got to do something
00:12:22
about that so uh uh anyway reaction time
00:12:27
is is more than just playing good video
00:12:29
games or or avoiding car accidents it's
00:12:32
a very good indicator of overall
00:12:34
cognitive Health um so it's uh I've
00:12:39
never seen somebody with Dementia or
00:12:42
Alzheimer's that uh has a uh you know
00:12:47
bad reaction time I mean they all have
00:12:48
bad re has good reaction time so gdf11
00:12:51
is the only known peptide regimen that
00:12:53
can lower a reaction time this a
00:12:55
biomarker that I'm very very into and
00:12:57
you all it's easy to take you just take
00:12:59
take it every day on the computer human
00:13:00
benchmark.com take you no time takes you
00:13:04
30 seconds a
00:13:05
day okay immune competency super
00:13:09
important uh the mechanism action behind
00:13:11
this is more active humano poetic cells
00:13:15
you know making uh more naive tea cells
00:13:17
and natural killers and you can see
00:13:19
everybody the most important uh immune
00:13:22
cell is naive te's uh these are the
00:13:24
cells that that uh figure out uh covid
00:13:27
and new pathogens and program the immune
00:13:29
system to amount of response and I'm
00:13:32
patient zero in eight years I went from
00:13:35
36 to 84 it's pretty good 133% up he's
00:13:38
still look at the guy who's age 33 he's
00:13:40
still way way ahead of me so uh it is
00:13:43
correlated with age it's another sad
00:13:46
biomarker you really can't do anything
00:13:49
about and once you fall below
00:13:51
10 you know you're in deep trouble then
00:13:54
you're you're walking candidate for uh
00:13:57
pneumonia and uh that's why I say if
00:14:00
nothing else gets you immunosenescence
00:14:02
will ask Jack Lan that guy did that guy
00:14:04
did everything right he died of amonia
00:14:07
at uh age 95 didn't address his uh naive
00:14:11
teas hoxygen reactivation okay this is
00:14:16
uh these are genes that control the size
00:14:18
and shape of our organs um we're very
00:14:22
good at uh reversing benign prostatic
00:14:24
hypertrophy BPH um the first sign you
00:14:28
have it is get up a lot in the middle of
00:14:29
the night to to go to the bathroom this
00:14:31
is for men obviously and uh we had one
00:14:34
guy that was uh hospitalized for it was
00:14:36
treated with uh uh catheters and I don't
00:14:39
really want to go into it but anyway
00:14:40
within a month he was uh he was fine so
00:14:43
the meod of a action here and there's a
00:14:45
couple papers on this all this is backed
00:14:47
up by the way with papers so not making
00:14:50
any of this up I'm just I'm just
00:14:52
reporting the human biom marketers for
00:14:53
you mechan of action is believed to be
00:14:55
switching on the Hax genes which control
00:14:57
the size of our organs
00:14:59
okay this is pretty cool I know
00:15:01
everybody loves scanalytics well gdf11
00:15:03
is probably the most powerful s analytic
00:15:05
there is it has to be it's about cell
00:15:07
proliferation you got more hematopoetic
00:15:09
cells making more nks and naive T's and
00:15:11
lucites and lipocytes you got to have
00:15:13
something on the other end or or put it
00:15:16
unscientifically you'd explode okay so
00:15:19
uh gf11 fed mice you see have a 45%
00:15:23
reduction in sessed liver sells
00:15:26
21.7% reduction in s kidney cells so
00:15:30
it's a very powerful antioxidant it's
00:15:33
endogenous you have it in you it's not a
00:15:35
cancer drug and uh I think that we're
00:15:38
going to for future gdf elers they're
00:15:40
all going to take Dr Shay's uh uh sa gal
00:15:44
uh test and I'll next radfest I'll let
00:15:46
you know about
00:15:49
this okay now let's talk about the
00:15:51
anti-cancer uh
00:15:53
capabilities
00:15:55
um you we have a GF eler his name is
00:15:58
Buzz he's here and about three years ago
00:16:01
he said my son's dog has a mano saroma
00:16:04
and I go amango what is that and he says
00:16:07
you know it's a cancer of the uh blood
00:16:09
cells blood V blood vessels and it's
00:16:12
very deadly dogs very rarely make it
00:16:14
Beyond three months and he said can I
00:16:16
give a gdf1 to the dog I said yeah let
00:16:19
me work of an allometric dose which is
00:16:21
basically just adjusting the dose for
00:16:24
dogs height and surface area and uh we
00:16:27
started injecting with gdf11 and uh
00:16:31
within a two months all his tumors were
00:16:33
gone yeah yeah so uh this is an Dodge of
00:16:36
his substance yes thank you so three
00:16:39
years later Dexter is cancer-free he's
00:16:43
yeah good Dex man this dog is and he's
00:16:45
running around of course his dogs DH
00:16:48
from the gdf1 so he's running around he
00:16:49
got a great coat he's the oldest living
00:16:52
manager saroma dog in the world yeah so
00:16:56
um so anyway I'm like oh wow that was
00:16:58
pretty cool you know let
00:17:06
Meo
00:17:08
har had no no choice about the needle
00:17:11
being stuck into with
00:17:19
gdf1 yeah thank you
00:17:22
[Applause]
00:17:23
buzz my publicists
00:17:27
yes
00:17:29
yeah so it was Buzz's idea this was not
00:17:31
my idea and I think I bet you 10 years
00:17:34
from now you know we're curing 100,000
00:17:36
people a year for uh with gdf1 thanks
00:17:39
thanks to buzz uh thinking way way
00:17:42
outside the box so uh also I love cats
00:17:45
so we got to spend some time on cats I
00:17:48
uh I have two myself they're both on
00:17:50
gdf1 they're doing great they're going
00:17:51
to make it to 30 uh this cat uh had
00:17:56
lymphoma this the first lymphoma cat we
00:17:59
tried it just goes to show you that gdf1
00:18:01
works basically at all Cancers and uh
00:18:04
yeah he's he's uh he's doing great he
00:18:07
was cured within a couple months no more
00:18:09
uh you know they usually have the
00:18:11
mandibular lymph nodes and the polyal
00:18:15
lymph nodes and We Shrunk those and the
00:18:17
cat's finally is going to go on to be
00:18:19
the oldest cat in the world okay what
00:18:21
what is the mechanism of action here now
00:18:25
you know everybody says they can cure
00:18:26
cancer thank God I got a great paper you
00:18:29
can read it's on Wikipedia it's called
00:18:31
gdf11 implications in cancer biology
00:18:35
metabolism and it's in the Journal of
00:18:37
nature so this is pretty credible stuff
00:18:41
and they they figured it out on mice I
00:18:43
figured it out on humans and dogs anyway
00:18:45
the best line of the paper is a blunt
00:18:47
fact regarding gf1 biology is that its
00:18:50
Target uh cells have stem this features
00:18:53
okay once again the stem cell aspect
00:18:54
comes in that could be found in in in
00:18:57
cancer cells so uh the way gdf1 works it
00:19:00
actually binds the cells with stemness
00:19:02
features and it suffocates them it
00:19:05
literally suffocates destroys their
00:19:06
mitochondrial function boom cell the
00:19:08
cancer cell's dead and we know this
00:19:10
paper is true because the dose we have
00:19:13
figured out is correlated with with
00:19:15
tumor load a dog or a cat that has a lot
00:19:17
of tumors need a thousand times a
00:19:20
thousand times what we take just because
00:19:23
the tumor load is so high so that this
00:19:25
paper is true on mice and I think we've
00:19:28
pretty much proven it to be true and
00:19:30
dogs and cats and I think humans are
00:19:32
just around the
00:19:33
corner okay here's our our our
00:19:36
scoreboard we've cured 12 Dogs We man of
00:19:38
saroma two of lymphoma uh one of lung
00:19:42
cancer one of a cancer I can't pronounce
00:19:45
hiso ciic saroma
00:19:48
insulinoma dogs with insulinoma that's
00:19:50
pretty interesting it's in the in the
00:19:52
islands of Langer horn they secrete
00:19:54
massive amounts of insulin but that dog
00:19:55
is fine too anyway uh they most likely
00:19:59
work against all cancers cuz all cancers
00:20:01
as far as gdf11 are concerned exhibit St
00:20:04
uh exhibit stus and when you think about
00:20:07
long list species natural selection has
00:20:09
to have a mechanism for controlling
00:20:11
stemis you know I mean boohead whales
00:20:13
live 250 years and you've never seen a
00:20:16
boohead whale in a Cancer Clinic
00:20:27
right
00:20:34
n

Description:

Steve Perry of GDF11Rejuvenation presents the seven main mechanisms of action of GDF11 and his own age reversal case in this clip. Stevel Perry Website: https://gdf11rejuvenation.com/ More on GDF11 https://en.wikipedia.org/wiki/GDF11 https://pubmed.ncbi.nlm.nih.gov/31144559/ https://pubmed.ncbi.nlm.nih.gov/31181098/ https://pubmed.ncbi.nlm.nih.gov/27509407/ https://pubmed.ncbi.nlm.nih.gov/35604508/ https://pubmed.ncbi.nlm.nih.gov/30729414/ https://pubmed.ncbi.nlm.nih.gov/33886503/ __________________________________________________________________________ Please note that the links below are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support! =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= ~*~ Discount Coupon Code: REVERSE 🌏ProHealth Longevity 15% OFF ~NEW~ Longevity Greens™ Powder https://www.prohealth.com/products/prohealth-longevity-greens-powder-342-grams-ph631?irclickid=0Ad1fG2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0&irgwc=1&clickid=0Ad1fG2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0 Calcium AKG Longevity 500mg Caps https://www.prohealth.com/products/prohealth-calcium-akg-longevity-500-mg-60-capsules-ph591?irclickid=0A50AF2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0&irgwc=1&clickid=0A50AF2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0 ProHealth Trans-Resveratrol 500mg Caps https://www.prohealth.com/products/prohealth-trans-resveratrol-1000-mg-60-capsules-ph528?irclickid=0AbxXq2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0&irgwc=1&clickid=0AbxXq2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0 Optimized Curcumin 500 mg https://www.prohealth.com/products/prohealth-optimized-curcumin-longvida-500-mg-60-capsules-ph403?irclickid=0AYyQ52kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0&irgwc=1&clickid=0AYyQ52kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0 Quercetin/Bromelain Complex https://www.prohealth.com/products/prohealth-quercetin-bromelain-complex-100-tablets-ph25?irclickid=0A5WVH2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0&irgwc=1&clickid=0A5WVH2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0 Full Spectrum Apigenin https://www.prohealth.com/products/prohealth-full-spectrum-apigenin-plus-60-capsules-ph621?irclickid=0A%3AxuS2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0&irgwc=1&clickid=0A%3AxuS2kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0 Green Tea EGCG Extreme™ https://www.prohealth.com/products/prohealth-green-tea-egcg-extreme-390-mg-100-capsules-ph395?irclickid=0AbVD82kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0&irgwc=1&clickid=0AbVD82kQxyKRasWF5xImTVPUkHXCQ2QrVov3M0 🔬Renue By Science 10% OFF Liposomal Fisetin https://renuebyscience.com/product/lipo-fisetin/?rfsn=7413184.e1d290 Liposomal Spermidine 8mg 10% OFF https://renuebyscience.com/product/lipo-spermidine-656165996902/?rfsn=7413184.e1d290 Lipo Quercetin 150mg https://renuebyscience.com/product/lipo-quercetin-powdered-liposomal-quercetin-capsules/ 🧬 DoNotAge 10% OFF All Products https://donotage.org/products SIRT6 Activator https://donotage.org/sirt6-activator 🔶 Nuchido Time+ Supplement FIRST ORDER 20% OFF Code : REVERSEAGING20 Restore Our Cells Ability To Make NAD Like When We Were Young ~ https://www.nuchido.com/REVERSEAGING 🍀 iHerb New Customer 20% OFF code: NEW20, existed customer 5% off Discount Link https://iherb.co/sUBAZcqw =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= --------------------------------------------------------------------------------------------------------------------------------------------------- DISCLAIMER: The information and opinions expressed in this video are for informational purposes only and are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult with your doctor or other qualified health provider before start taking any supplements. OleicAcid #NAD #Sirtuins #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome

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