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Russian
00:00:02
hello all good people, I want00:00:04
to introduce you to the mechanism of action of00:00:06
drugs that are00:00:08
truly00:00:09
wonderful and magical in terms of00:00:12
weight loss by 10 20 30 kilograms,00:00:15
while not requiring any effort on00:00:19
your part, this is indeed00:00:21
possible, apparently medicine has come to00:00:23
the time when, if you have00:00:26
certain means, you can00:00:27
buy yourself a little health, that is, you do00:00:30
n’t have to strain yourself, don’t resort to any00:00:32
diets, live your normal life and00:00:36
take certain pills or injections and00:00:39
start losing weight, and do it00:00:41
efficiently without violence against yourself, but00:00:44
also these drugs can help people00:00:46
who desperate to lose weight, who00:00:49
make every possible effort, but00:00:52
still their weight remains the same,00:00:55
or for those people who simply do not have00:00:57
the opportunity or time to00:00:59
take care of themselves, so these are drugs00:01:03
called glucagon agonists of a00:01:05
similar peptide in order to00:01:08
understand how they work you need to know00:01:11
what glucagon-like peptide is,00:01:13
where it is produced, what functions it00:01:15
has, let me00:01:16
briefly remind you that a hormone is a00:01:20
molecule that interacts with a00:01:22
certain structure on cells, this00:01:25
structure is called receptors, that is, a00:01:27
hormone and a receptor are a00:01:30
system similar to a key and a lock, a hormone in00:01:34
our case this is a key and the lock is a00:01:37
receptor, that is, the key is inserted into the00:01:39
lock, it turns, it opens the door or00:01:42
some other action it performs in00:01:44
this way and00:01:46
hormones interact with their00:01:48
receptors, and there is a whole class of00:01:51
drugs that act on the same00:01:54
receptors as glucagon-like00:01:57
peptide 1 and00:01:58
accordingly cause the same00:02:01
effects that this hormone produces, I00:02:05
would like to take this opportunity00:02:06
to inform you that if you have00:02:08
problems gaining excess weight, you00:02:11
are constantly struggling with gaining00:02:13
extra pounds, this comes to you with00:02:15
great effort, then I have a00:02:18
special course called00:02:21
reprogram the body and00:02:22
become slim forever this course will allow you00:02:25
to lose weight permanently be slim without00:02:28
making any effort00:02:30
also I have a course for people who are00:02:32
struggling with high blood00:02:34
pressure with hypertension this course00:02:37
is called how to cure hypertension without00:02:40
drugs and finally I also have a00:02:42
course for those people who are00:02:44
interested in increasing00:02:45
their life expectancy and especially00:02:49
in increasing the healthy00:02:51
life expectancy of preventing old age and00:02:53
preserving youth as long as possible and00:02:57
you can see links to all these courses00:03:00
in the description under this video, here I00:03:03
drew a diagram of the brain, this is the00:03:07
brain stem, this is the stomach is the00:03:10
pancreas, this is the00:03:12
duodenum and the initial00:03:15
part of the small intestine, that is, the00:03:18
jejunum is a piece of the ileum and,00:03:21
accordingly, the large intestine.00:03:23
Glucagon, a similar peptide,00:03:26
is produced in humans in two places00:03:28
in the00:03:29
central nervous system, there is a00:03:32
place called the00:03:33
nucleus of the sanitary tract, this is the first place00:03:38
where this hormone is produced and the00:03:41
second place is mainly the00:03:45
distal part of the small intestine,00:03:48
namely the ileum and00:03:50
part of the00:03:52
large intestine with red dots,00:03:55
for example, I indicate those places where00:03:57
glucagon-like peptide00:04:00
1 is produced, well, of course, it is not produced there by the00:04:04
intestinal cells themselves,00:04:06
I’ll add the brain so that we Haven’t00:04:09
you forgotten that glucagon like people00:04:12
and one and00:04:14
here we also produce blue go00:04:17
on similar and birds one and so00:04:20
it is produced by the so-called elf00:04:22
cells which are00:04:25
endocrine cells of the00:04:27
intestine; in fact, there are a00:04:30
lot of endocrine cells in the intestine and these are00:04:33
some of them them, this is the most powerful00:04:35
endocrine system in humans in general, so this is00:04:39
what it is produced from, glucagon-00:04:42
like peptide one is a yang [ __ ], that00:04:45
is, a hormone that depends on the00:04:46
intake of food and therefore naturally the00:04:50
entry of food into the stomach will00:04:53
cause an increase in the secretion of glucagon-00:04:57
like peptide 1, and at the beginning this is00:05:00
secretion is caused by stimulation of the nervous00:05:04
system through nerve endings, that is,00:05:07
glucagon-00:05:09
like peptide 1 rises very quickly and then,00:05:12
as the food moves through the intestines,00:05:15
after it reaches those00:05:18
areas here that are00:05:20
responsible for the production of glucagon-00:05:23
like peptide, in fact, there is00:05:24
also their stomachs have these00:05:27
areas in their red there are significantly fewer of them00:05:29
and in the jejunum00:05:33
they are like this,00:05:35
glucagon-like peptide 1 was released and00:05:39
why was it released and because its00:05:42
function is to immediately reduce the concentration of00:05:45
glucose in the blood and therefore it immediately00:05:49
affects the pancreas and00:05:52
pancreas gland, as you know, there are00:05:55
beta cells00:05:57
beta cells there are alpha cells beta00:06:01
cells produce00:06:02
insulin and alpha cells00:06:05
produce glucagon00:06:08
I draw insulin00:06:12
[music]00:06:13
when i00:06:17
alpha cells produce00:06:19
glucagon and00:06:24
so00:06:26
glucagon-like peptide00:06:29
increases the level of insulin and00:06:33
lowers the level of glucagon because that00:06:35
insulin lowers our sugar,00:06:38
glucagon, on the contrary, increases sugar, in00:06:42
addition,00:06:43
glucagon-like peptide helps to00:06:47
increase the number of00:06:49
beta cells in the00:06:51
pancreas and generally helps to improve00:06:55
its function, but it suppresses glucagon not in such a00:07:01
crazy way, but until the moment when the00:07:04
glucose level does not drop below than00:07:08
it should be, if we already have less than the00:07:11
lower level of glucose, then00:07:13
everything on glucagon stops acting and00:07:16
glucagon begins to be secreted again,00:07:19
therefore, when exposed to glucagon00:07:22
of a similar peptide,00:07:25
hypoglycemia never occurs, but besides this00:07:28
action, then by the way I will explain to you why00:07:31
it is still used for treatment in00:07:33
patients with diabetes mellitus,00:07:35
in addition to this effect, glucagon also has a00:07:39
similar peptide effect on the stomach, that00:07:42
is, it slows down the evacuation, I write00:07:45
evacuation, this removal00:07:54
is the removal of food from the stomach, that is, it00:07:58
reduces and it also00:08:03
reduces the secretion of hydrochloric acid, that00:08:07
is, hydrochloric00:08:11
acid00:08:14
drops and, accordingly, the acidity of00:08:17
gastric juice the00:08:22
next thing it does also falls: it affects the00:08:25
brain and in the brain it00:08:29
causes such things as a00:08:32
decrease in appetite,00:08:38
that is, I’m writing here, our appetite falls on the00:08:43
one hand, on the other hand, our00:08:48
feeling of00:08:49
hunger decreases,00:08:54
hunger decreases,00:08:57
saturation00:09:05
decreases, and00:09:08
another very important function this is neuro00:09:12
protection00:09:14
neuro00:09:17
damage00:09:20
so00:09:23
you me00:09:26
what is neuro protection this is an00:09:29
obstacle to age-related changes in00:09:32
dementia and Alzheimer's disease00:09:36
Parkinson's disease and it is even believed to00:09:39
reduce the progression of multiple00:09:42
sclerosis00:09:43
in addition to00:09:45
glucagon-like peptides it00:09:48
also turns out to have a beneficial effect on the heart00:09:52
I draw the heart,00:09:55
that is, it improves function00:09:59
hearts,00:10:00
in addition, it improves kidney function,00:10:05
I draw a kidney,00:10:10
in addition, it improves00:10:15
bone mineralization, strengthens bones,00:10:19
in addition, it improves lung function,00:10:27
and of course, as it should be, since00:10:32
it secretes insulin, it improves the00:10:36
volume of adipose tissue,00:10:42
but the effect of glucagon is similar to a peptide for a00:10:45
very short time, in fact here is its00:10:48
release into the bloodstream and also00:10:51
literally spreads through00:10:53
nearby intestinal cells within00:10:56
one to two minutes, why because there is an00:11:00
enzyme called00:11:07
dipeptidyl peptidase-400:11:11
dipeptidyl peptidase-4 type 4, this00:11:15
enzyme very quickly destroys00:11:18
glucagon-like peptide 1 and00:11:22
accordingly, it lives for one or two minutes,00:11:24
there is another00:11:26
neutral end of the peptide for which they also00:11:30
take part in the00:11:34
breakdown of00:11:36
our glucagon, a similar peptide00:11:39
is designated as no00:11:41
2411, which is why glucagon-like00:11:45
peptide lives very briefly, but due to the fact00:11:50
that it has a very good00:11:52
property, of course, that00:11:54
interests us now we will discuss them, they00:12:00
invented drugs that act00:12:03
on the same receptors as glucagon-00:12:06
like peptide 1, that is, they00:12:09
act in the same way on the00:12:11
brain on the stomach on the pancreas00:12:14
on the bones on the lungs on everything all everything I mean00:12:18
that glucagon is similar to pi pi don00:12:20
by itself does not cause some kind of00:12:22
change, it interacts with00:12:24
structures on the cells of all00:12:26
these organs, these structures00:12:28
are called receptors, respectively,00:12:31
the hormone is like a key to a lock, it fits00:12:34
certain recipes, turns on this00:12:36
lock, and then this effect occurs in all these organs00:12:38
which I00:12:41
told, and just for information00:12:44
about me, a glucagon-like peptide00:12:47
still exists with a similar effect. The00:12:50
peptide is also produced in00:12:52
the intestines, wherever it is warned in the00:12:55
darkness, it is called GIP, which stands for glucagon-00:12:59
dependent00:13:03
insulin tropic nourishes or glucose-00:13:06
dependent insulin-like peptide that00:13:09
is, both JP and Jail00:13:13
p1 belong to the class of cretins, that00:13:17
is, these are hormones of the digestive system00:13:19
that are produced under the influence of00:13:22
food entering our body. It naturally00:13:26
reacts to glucose,00:13:30
as you see, glucagon is a similar peptide that00:13:33
has a lot of excellent00:13:36
properties, but the listeners are attentive,00:13:39
of course. they will ask a question, and even I00:13:42
asked myself the same question: how can a hormone or a00:13:46
drug based on it that increases00:13:49
insulin somehow00:13:52
reduce a person’s body weight? It’s a paradox;00:13:55
it’s true, because lately we’ve all been00:13:59
hearing about00:14:00
insulin resistance, pre-diabetes,00:14:04
metabolic syndrome, that diet,00:14:06
reduce insulin there to some00:14:09
incredibly low amounts, otherwise everything is00:14:12
terrible, terrible00:14:14
and just a disaster, so it turns out00:14:17
no physiology is a much more00:14:20
interesting thing than you might think,00:14:23
first of all, it’s not so bad for people00:14:26
who already have00:14:28
type 2 diabetes and whose00:14:31
pancreas is depleted iron because00:14:34
type 2 diabetes sooner or later00:14:36
ends with the prescription of insulin00:14:39
if the person did not take anything there,00:14:42
why simply insulin, which00:14:44
is produced by the pancreas of a00:14:46
person with type 2 diabetes,00:14:49
ceases to be produced in the required00:14:51
quantities and, in the end, when a00:14:54
person eats some food insulin00:14:57
is not enough to lower00:14:59
glucose levels and now let’s ask ourselves00:15:02
what is worse: high levels of glucose00:15:05
constant in the blood or high levels of00:15:08
insulin, the answer is high levels of glucose are00:15:11
much worse, it destroys our00:15:14
body more, so here is the effect of00:15:18
glucagon-like peptide 1 or00:15:20
drugs that resemble it00:15:23
the action is already good since they reduce, no matter how, the00:15:27
sugar level,00:15:30
then remember that glucagon-like00:15:34
peptide alone causes a decrease in00:15:37
appetite and an increase in the feeling of satiety,00:15:41
then it inhibits the emptying of the stomach00:15:45
from eaten food and it reduces the00:15:48
secretion of gastric juice, all these00:15:52
components together lead to00:15:55
because a person loses his appetite,00:15:58
he has everything he wants on00:16:01
the table with his eyes, as if from old00:16:04
memory, and he could eat it, well, he doesn’t climb, that’s00:16:07
what they call, he doesn’t climb, he doesn’t want00:16:09
to eat a little and that’s all that00:16:12
leads to Yes, besides, the less00:16:13
a person eats,00:16:15
the lower his blood glucose level,00:16:17
and the lower the blood glucose level,00:16:20
the less insulin is released and,00:16:24
accordingly, in the end, these00:16:27
drugs that act on00:16:30
glucagon receptors like peptide 100:16:33
lead to the fact that a person drives less00:16:36
it increases insulin less,00:16:38
sugar increases less, and thus a person00:16:42
sooner or later begins to lose weight, but00:16:46
besides, of course, it has many00:16:49
beneficial effects, well, who00:16:51
doesn’t like, for example, being00:16:53
prevented from Alzheimer’s disease00:16:56
from some kind of mental degradation from00:16:58
Parkinson’s disease, preserve your liver00:17:01
bones and so on, all this provides00:17:04
us with glucagon receptor agonists00:17:07
similar to peptide 1 and, accordingly,00:17:10
the drugs that were developed on the00:17:13
basis of this hormone differ from it00:17:16
only in that they have a00:17:19
longer half-life, but this is00:17:22
such a pharmacological value as the00:17:25
half-life of00:17:27
radioactive elements, in the same way00:17:30
there is such The half-life00:17:32
of drugs of earlier00:17:35
generations, for example, is Lera Gluten or Vic Pose00:17:38
or Saxin, and they have an expiration date of 2400:17:42
hours, that is, they must be injected every day,00:17:45
but drugs of more recent generations00:17:49
such as Dulo Krutit or Sema Gluten00:17:52
already have an expiration date of about seven days, that00:17:56
is, they can be injected once a week, but00:18:00
at the same time, the chest or even got to the point where they came up with the idea of00:18:03
using it in tablets,00:18:06
that is, those people who do not want a well are00:18:09
afraid, they can just take00:18:11
tablets; the only thing these drugs00:18:14
can have as a side effect is nausea and00:18:18
sometimes even vomiting, in order to prevent this from00:18:20
happening, you need to gradually00:18:23
start taking them, that is, gradually00:18:25
increase the dosage, so00:18:28
you need to increase the dosage gradually00:18:31
because if it is taken immediately00:18:33
and at a working dose, it00:18:35
can develop due to the fact that00:18:38
gastric emptying slows down. it may00:18:41
simply become an upset stomach and00:18:43
vomiting and nausea may occur; this is a long way off, that00:18:45
is, unpleasant things, so you need to00:18:47
slowly get used to them, and when a00:18:49
person gets used to it, he doesn’t suffer from hunger, he00:18:53
begins to eat less, he starts to lose weight, and00:18:56
he can do this for00:18:58
basically six months or a year.00:19:00
will fit for some people is00:19:03
useful this strategy is very simple it is00:19:06
difficult to lose some unfortunate 1000:19:09
kilograms but they cannot lose them00:19:12
with the help of these drugs then00:19:15
start just an ordinary normal diet00:19:18
and that’s all in this way,00:19:21
now there is an opportunity for lazy00:19:25
people or for people for whom nothing00:19:28
works, make your fate a little easier,00:19:30
these are some interesting preparations on the00:19:34
topic of everything I listened to here and until the end00:19:36
hiace to cool down and glory to UkraineDescription:
Для записи на персональную консультацию: https://ecarium.clinic/ Почта: [email protected] Телефон: +380953229612 ----------------------------------------------------------------------------------------------------------------------------------------- Курс «Как победить старение организма. Практическое руководство» https://www.udemy.com/course/romikwvf/?referralCode=ED03F182A33DF76AF0FF Курс «Как перепрограммировать организм и навсегда стать стройным» https://www.udemy.com/course/bxbphbez/?referralCode=5C93AF4FDA5AC278AB64 Курс «Лечение гипертонии без лекарств» https://www.udemy.com/course/vhqksohh/?referralCode=7BB94125D1E8D3A12063 Избавиться от лишнего жира можно не только путем диет и физических упражнений. Можно вообще ничего не делать, а просто колоть уколы и ли принимать таблетки и ваш вес может снизиться на 10-30 килограммов. Это подходит людям, которые не могут заставить себя изменить образ жизни или тем, кто отчаялся. Препараты данной группы называют агонистами рецепторов глюкагоноподобного пептида
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