Download "Osteomyelitis | Symptoms & Causes🩺"

Osteomyelitis | Symptoms & Causes🩺 Like this video? Sign up now on our website at https://www.drnajeeblectures.com/ to access 800+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $99 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 800+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ Defining Osteomyelitis (OM); Pyogenic & non-pyogenic infections. STAPH. AUREUS; most common organism in pyogenic OM & importance of this fact in directing empirical antibiotic therapy. Mycobacterium Tuberculosis; most common organism in non-pyogenic OM. POTT'S DISEASE; OM involving vertebrae; common in adults. Routes of entry of organism into Bone Marrow (BM): 1-Hematogenous spread/route. OM in children; long bone internal anatomy explained; significance of involvement of Metaphysis of long bones in OM of children. Pott’s Disease; vertebral involvement through hematogenous route; Bacteremia. Routes of entry continued; 2-Direct extension from neighboring Soft Tissue Infections; periosteal breach, example: DIABETIC FOOT ULCER. Mechanism of development of Diabetic Foot Ulcer: Atherosclerosis & Ischemia, Immunocompromised & Infection, DIABETIC NEUROPATHY & inadvertent repetitive trauma. Ulcer deepens to the level of bones leading to OM. 3-Microbes’ direct implantation into bone: Penetrating injury, surgery & Open Fractures. Pathophysiology of Osteomyelitis (OM): Blood supply in long bones; nutrient artery; significance of Hair Pin Turn Loops. Pathophysiology of OM continued: High rates of OM in children; settling of bacterial infection in Hair Pin Turn Loops of Metaphysis occurs relatively easily, for following reasons: 1-Blood flow pattern favors the bacterial settling in the metaphysis. 2-Low phagocytic cell activity. 3-Bacteria express cell surface molecules that help bacteria attach itself to collagen, fibronectin; stay there and multiply. Staph. Aureus; SUPPURATIVE INFLAMMATION; spread of pus along the path of least resistance; pattern of spread of pus & its relation with distribution pattern of Metaphyseal & Epiphyseal Vessels in children younger than 1 year & older than 1 year; significance of avascular epiphyseal plate in children older than 1 year. SUPPURATIVE SEPTIC ARTHRITIS; [in infants younger than 1 year] interconnection b/w Epiphyseal & Metaphyseal vessels; destruction of articular cartilage & permanent damage to joints. Pathophysiology of OM continued: microscopic structure of long bones is described; Osteons, HAVERSIAN CANALS & Osteocytes. Cross & Longitudinal section of Haversian Canal/Osteon; Horizontal Vascular interconnections b/w neighboring Haversian Canals; VOLKMANN CANALS. Haversian System in detail; Periosteum, Periosteal & Cortical arteries. Pathophysiology of OM continued: Development of SUB PERIOSTEAL ABSCESS; severing of periosteal vessels; NECROSIS. Destruction, thrombosis of blood supply from Medullary & Periosteal side; disconnection from any functional vascular system; ISCHEMIC NECROSIS of involved segment of the bone; DEAD piece of bone; SEQUESTRUM. Conversion of ACUTE OM into CHRONIC OM. Pathophysiology of OM continued: PERIOSTEAL REACTION; arrival of Mesenchymal Osteoprogenitor Cells (“Sleepy Cells”); conversion into Osteocytes & new bone formation in lifted periosteum; REACTIVE BONE FORMATION. Formation of INVOLUCRUM; newly formed vascular bone with no defined structure. Long-term complications; Sub periosteal pus may rupture into surrounding tissues; involucrum partly digested, pus coming out through openings in the soft tissue; formation of CLOACA, SINUSES & epithelization of sinuses. Need for surgical removal. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast https://www.youtube.com/channel/UCPHpx55tgrbm8FrYYCflAHw/join Follow us on Facebook :- https://www.facebook.com/unsupportedbrowser Follow us on Instagram :- https://www.facebook.com/unsupportedbrowser