Herunterladen "Uncovering New Longevity Research DISCOVERIES: The Power of 3HAA Revealed | 12 - George Sutphin"

Subscribe to our channel: https://www.youtube.com/@optispan The Sutphin Lab: https://sutphinlab.org/ University of Arizona Assistant Professor of Molecular and Cellular Biology George Sutphin runs a lab that investigates genetic determinants of longevity, the effects of kynurenine-based interventions on lifespan, and environmental regulators of the aging process. George, who was an aerospace engineer before he discovered the promise of geroscience, completed his PhD at the University of Washington and worked as a postdoctoral associate at the Jackson Laboratory prior to his current faculty position. He currently serves as Chairperson of the American Aging Association. We sat down with George to talk about his research, including the effects of caffeine on lifespan and, more recently, his discovery of a new metabolite with the ability to greatly extend lifespan when given late in life. We also discuss George's thoughts on biological age clocks, his own healthspan optimization protocol, and much more. 0:00 Trailer 0:38 Introduction 1:56 How George became interested in geroscience 6:51 George's favorite geroscience project in his PhD 8:14 Caffeine extends life- and healthspan in worms 11:15 Dietary restriction extends lifespan in worms 21:54 Thoughts on biological aging clocks 28:12 Working at the Jackson Laboratory, a nonprofit biomedical research institution that mimics a university academic department 30:47 Worm orthologs of human genes whose expression changes with age are enriched for determinants of longevity 39:17 How many of the genes in the genome could potentially have an effect on lifespan? 41:23 Graph showing which genes increased lifespan in worms 47:50 The kynurenine pathway and its role in lifespan extension 1:01:29 Feeding 3-Hydroxyanthranilic acid (3HAA) to worms increases lifespan 1:05:04 Does NAD+ tie into this pathway? 1:06:55 Replicating the findings in mice 1:09:48 Variation in human 3HAA levels 1:10:28 Can one buy 3HAA? 1:12:16 Testing 3HAA supplementation in mice 1:19:24 3HAA's role in mice immune function 1:22:35 Does George take 3HAA supplements? 1:24:16 George's personal health journey 1:25:46 Finding a doctor who takes a healthspan approach to medicine 1:26:26 How frequently George gets bloodwork done 1:27:51 George's exercise strategy 1:28:59 DEXA scans 1:29:28 Intermittent fasting 1:31:02 George's diet 1:31:43 How Matt achieves his protein goals 1:33:42 Supplements and cultural biases about aging 1:42:02 George's rapamycin protocol 1:47:55 George's experiences with Continuous Glucose Monitoring (CGM) 1:56:51 The American Aging Association 2:01:40 Lighting round Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!